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- W2008102897 abstract "In the present study, the effect of systemically administered vasoactive intestinal peptide (VIP) (25 ng/kg i.p.) was investigated on drug-induced rotational behavior, extra-cellular dopamine levels and histology of corpus striatum in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. After 15 days of 6-OHDA lesion, apomorphine-induced (0.05 mg/kg s.c.) rotational behavior of the animals significantly increased and extra-cellular dopamine levels of corpus striatum were significantly reduced. VIP reversed the rotational deficits but did not alter the decrease in striatal dopamine levels. On the other hand, histological data indicate that VIP significantly reduced neuronal death and demyelination. Electron microscopic appearance of mast cells showed ultra-structural variety between VIP-treated and 6-OHDA lesioned groups. VIP activates mast cells without any evidence of typical exocytosis, and possibly mast cells could participate in neuroprotection. Our results suggest that systemically administered VIP can attenuate the motor response changes, neuronal cell death, and myelin sheet loss characteristically associated with 12 μg 6-OHDA administration into the rat striatum. Brain mast cells seem to participate in neuronal protection. Possibly, protective cues could be produced by brain mast cells." @default.
- W2008102897 created "2016-06-24" @default.
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- W2008102897 date "2005-05-01" @default.
- W2008102897 modified "2023-10-18" @default.
- W2008102897 title "Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: Brain microdialysis, behavior, and microscopy" @default.
- W2008102897 cites W1520138005 @default.
- W2008102897 cites W1590012920 @default.
- W2008102897 cites W1883604772 @default.
- W2008102897 cites W1965590767 @default.
- W2008102897 cites W1965851255 @default.
- W2008102897 cites W1968902391 @default.
- W2008102897 cites W1969911722 @default.
- W2008102897 cites W1976694824 @default.
- W2008102897 cites W1976724667 @default.
- W2008102897 cites W1977026907 @default.
- W2008102897 cites W1978471007 @default.
- W2008102897 cites W1978865062 @default.
- W2008102897 cites W1978900962 @default.
- W2008102897 cites W1984834458 @default.
- W2008102897 cites W1986586827 @default.
- W2008102897 cites W1993091864 @default.
- W2008102897 cites W1993569854 @default.
- W2008102897 cites W1993753481 @default.
- W2008102897 cites W1994577623 @default.
- W2008102897 cites W1995049674 @default.
- W2008102897 cites W1997063937 @default.
- W2008102897 cites W2000942652 @default.
- W2008102897 cites W2001775202 @default.
- W2008102897 cites W2003531324 @default.
- W2008102897 cites W2004847111 @default.
- W2008102897 cites W2015394803 @default.
- W2008102897 cites W2016267039 @default.
- W2008102897 cites W2016695367 @default.
- W2008102897 cites W2023347036 @default.
- W2008102897 cites W2024747291 @default.
- W2008102897 cites W2024905784 @default.
- W2008102897 cites W2025099349 @default.
- W2008102897 cites W2025593045 @default.
- W2008102897 cites W2026200164 @default.
- W2008102897 cites W2031350346 @default.
- W2008102897 cites W2033964949 @default.
- W2008102897 cites W2044511801 @default.
- W2008102897 cites W2047391965 @default.
- W2008102897 cites W2050709677 @default.
- W2008102897 cites W2053400919 @default.
- W2008102897 cites W2054600993 @default.
- W2008102897 cites W2056707198 @default.
- W2008102897 cites W2059036105 @default.
- W2008102897 cites W2061233445 @default.
- W2008102897 cites W2065545181 @default.
- W2008102897 cites W2067523166 @default.
- W2008102897 cites W2067692195 @default.
- W2008102897 cites W2068337064 @default.
- W2008102897 cites W2069998824 @default.
- W2008102897 cites W2070157281 @default.
- W2008102897 cites W2072756227 @default.
- W2008102897 cites W2076837836 @default.
- W2008102897 cites W2077032946 @default.
- W2008102897 cites W2077152493 @default.
- W2008102897 cites W2080000111 @default.
- W2008102897 cites W2081490305 @default.
- W2008102897 cites W2081583081 @default.
- W2008102897 cites W2083149462 @default.
- W2008102897 cites W2084187917 @default.
- W2008102897 cites W2089682532 @default.
- W2008102897 cites W2090476662 @default.
- W2008102897 cites W2090940022 @default.
- W2008102897 cites W2093680323 @default.
- W2008102897 cites W2095566323 @default.
- W2008102897 cites W2101962512 @default.
- W2008102897 cites W2102284349 @default.
- W2008102897 cites W2102596419 @default.
- W2008102897 cites W2104130513 @default.
- W2008102897 cites W2110030159 @default.
- W2008102897 cites W2122857482 @default.
- W2008102897 cites W2126390843 @default.
- W2008102897 cites W2128772172 @default.
- W2008102897 cites W2131781038 @default.
- W2008102897 cites W2137789711 @default.
- W2008102897 cites W2156507740 @default.
- W2008102897 cites W2168452018 @default.
- W2008102897 cites W2170885598 @default.
- W2008102897 cites W2172263281 @default.
- W2008102897 cites W2230882011 @default.
- W2008102897 cites W2344605681 @default.
- W2008102897 cites W242690426 @default.
- W2008102897 cites W4211212356 @default.
- W2008102897 cites W4313331694 @default.
- W2008102897 doi "https://doi.org/10.1016/j.peptides.2004.12.019" @default.