FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008103622> ?p ?o ?g. }

• W2008103622 abstract "A bstract : Background: Sesamin, a major lignan in sesame seeds, has multiple functions such as stimulation effect of ethanol metabolism in mice and human, and prevention of ethanol‐induced fatty liver in rats. However, the mechanism has not been clarified yet. Methods: The changes of gene expression were investigated in rats given 250 mg/kg of sesamin (sesamin rats) or vehicle (control rats) for three days by using a DNA microarray analysis. At 4 hr after the final ingestion, the profiles of gene expression in rat livers were compared. Results: The analysis showed that 38 transcripts were up‐regulated with a significant change of more than two‐fold and eight transcripts were down‐regulated with a significant change to less than half in the livers of sesamin rats versus control rats. The gene expression levels of the early stage enzymes of β‐oxidation including long‐chain acyl‐CoA synthetase, very long‐chain acyl‐CoA synthetase and carnitine palmitoyltransferase were not changed, however, those of the late stage enzymes of β‐oxidation including trifunctional enzyme in mitochondria, and acyl‐CoA oxidase, bifunctional enzyme and 3‐ketoacyl‐CoA thiolase in peroxisomes, were significantly increased by sesamin ingestion. Also, in sesamin rats, the gene expression of aldehyde dehydrogenase was increased about three‐fold, whereas alcohol dehydrogenase, liver catalase and CYP2E1 were not changed. Changes in the gene expression of alcohol‐ and aldehyde‐metabolizing enzymes observed in a DNA microarray were also confirmed by a real‐time PCR method. Conclusions: These results suggested that sesamin ingestion regulated the transcription levels of hepatic metabolizing enzymes for alcohol and lipids." @default.
• W2008103622 created "2016-06-24" @default.
• W2008103622 creator A5004388848 @default.
• W2008103622 creator A5017148445 @default.
• W2008103622 creator A5020299156 @default.
• W2008103622 creator A5055494822 @default.
• W2008103622 creator A5061603352 @default.
• W2008103622 date "2005-11-01" @default.
• W2008103622 modified "2023-10-01" @default.
• W2008103622 title "Sesamin Ingestion Regulates the Transcription Levels of Hepatic Metabolizing Enzymes for Alcohol and Lipids in Rats" @default.
• W2008103622 cites W1479733192 @default.
• W2008103622 cites W1530519259 @default.
• W2008103622 cites W1963485079 @default.
• W2008103622 cites W1966654138 @default.
• W2008103622 cites W1982902225 @default.
• W2008103622 cites W2031846075 @default.
• W2008103622 cites W2033035026 @default.
• W2008103622 cites W2045525214 @default.
• W2008103622 cites W2048652573 @default.
• W2008103622 cites W2055679906 @default.
• W2008103622 cites W2064009707 @default.
• W2008103622 cites W2071130616 @default.
• W2008103622 cites W2075775046 @default.
• W2008103622 cites W2083534024 @default.
• W2008103622 cites W2091201900 @default.
• W2008103622 cites W2124345456 @default.
• W2008103622 cites W2157530875 @default.
• W2008103622 cites W2159868923 @default.
• W2008103622 cites W2171992272 @default.
• W2008103622 cites W2318372108 @default.
• W2008103622 doi "https://doi.org/10.1097/01.alc.0000189296.99704.1f" @default.
• W2008103622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16344595" @default.
• W2008103622 hasPublicationYear "2005" @default.
• W2008103622 type Work @default.
• W2008103622 sameAs 2008103622 @default.
• W2008103622 citedByCount "29" @default.
• W2008103622 countsByYear W20081036222012 @default.
• W2008103622 countsByYear W20081036222013 @default.
• W2008103622 countsByYear W20081036222014 @default.
• W2008103622 countsByYear W20081036222016 @default.
• W2008103622 countsByYear W20081036222017 @default.
• W2008103622 countsByYear W20081036222018 @default.
• W2008103622 countsByYear W20081036222019 @default.
• W2008103622 countsByYear W20081036222020 @default.
• W2008103622 crossrefType "journal-article" @default.
• W2008103622 hasAuthorship W2008103622A5004388848 @default.
• W2008103622 hasAuthorship W2008103622A5017148445 @default.
• W2008103622 hasAuthorship W2008103622A5020299156 @default.
• W2008103622 hasAuthorship W2008103622A5055494822 @default.
• W2008103622 hasAuthorship W2008103622A5061603352 @default.
• W2008103622 hasConcept C104317684 @default.
• W2008103622 hasConcept C140027455 @default.
• W2008103622 hasConcept C150194340 @default.
• W2008103622 hasConcept C153911025 @default.
• W2008103622 hasConcept C181199279 @default.
• W2008103622 hasConcept C185592680 @default.
• W2008103622 hasConcept C25747580 @default.
• W2008103622 hasConcept C2776317432 @default.
• W2008103622 hasConcept C2776513503 @default.
• W2008103622 hasConcept C2777344606 @default.
• W2008103622 hasConcept C2778435403 @default.
• W2008103622 hasConcept C2781031557 @default.
• W2008103622 hasConcept C31532488 @default.
• W2008103622 hasConcept C31903555 @default.
• W2008103622 hasConcept C526171541 @default.
• W2008103622 hasConcept C55493867 @default.
• W2008103622 hasConcept C62231903 @default.
• W2008103622 hasConcept C84693403 @default.
• W2008103622 hasConcept C86803240 @default.
• W2008103622 hasConceptScore W2008103622C104317684 @default.
• W2008103622 hasConceptScore W2008103622C140027455 @default.
• W2008103622 hasConceptScore W2008103622C150194340 @default.
• W2008103622 hasConceptScore W2008103622C153911025 @default.
• W2008103622 hasConceptScore W2008103622C181199279 @default.
• W2008103622 hasConceptScore W2008103622C185592680 @default.
• W2008103622 hasConceptScore W2008103622C25747580 @default.
• W2008103622 hasConceptScore W2008103622C2776317432 @default.
• W2008103622 hasConceptScore W2008103622C2776513503 @default.
• W2008103622 hasConceptScore W2008103622C2777344606 @default.
• W2008103622 hasConceptScore W2008103622C2778435403 @default.
• W2008103622 hasConceptScore W2008103622C2781031557 @default.
• W2008103622 hasConceptScore W2008103622C31532488 @default.
• W2008103622 hasConceptScore W2008103622C31903555 @default.
• W2008103622 hasConceptScore W2008103622C526171541 @default.
• W2008103622 hasConceptScore W2008103622C55493867 @default.
• W2008103622 hasConceptScore W2008103622C62231903 @default.
• W2008103622 hasConceptScore W2008103622C84693403 @default.
• W2008103622 hasConceptScore W2008103622C86803240 @default.
• W2008103622 hasIssue "s2" @default.
• W2008103622 hasLocation W20081036221 @default.
• W2008103622 hasLocation W20081036222 @default.
• W2008103622 hasOpenAccess W2008103622 @default.
• W2008103622 hasPrimaryLocation W20081036221 @default.
• W2008103622 hasRelatedWork W1599448530 @default.
• W2008103622 hasRelatedWork W2008103622 @default.
• W2008103622 hasRelatedWork W2012147678 @default.
• W2008103622 hasRelatedWork W2075784540 @default.
• W2008103622 hasRelatedWork W2083207745 @default.
• W2008103622 hasRelatedWork W2143734654 @default.
• W2008103622 hasRelatedWork W2380880325 @default.

• next