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• W2008103633 abstract "<i>Background/Aims:</i> Accumulating biological and epidemiological evidence suggests a close link between cholesterol metabolism and the pathophysiology of Alzheimer’s disease (AD). The observation that the use of statins reduces the risk of AD sustains this hypothesis. Apolipoprotein A-I (APOA1) is the major component of the high-density lipoproteins, particles involved in reverse cholesterol transport. Therefore, genetic polymorphisms in the gene encoding APOA1 might influence cholesterol metabolism and be a risk factor for AD. A previous study suggested an impact of a G→A polymorphism at position –75 bp in the <i>APOA1</i> gene on the risk for early-onset AD and on the age at onset of the disease. We studied this polymorphism in 3 independent European population samples. <i>Methods:</i> Genotyping was conducted asdescribed in the previous study. <i>Results:</i> We were unable to show any impact of this polymorphism on the risk of AD. Conversely, subjects bearing the A allele of this polymorphism were at risk of cognitive decline. <i>Conclusion:</i> Our resultssuggest an impact of the G→A polymorphism at position –75 bp in the <i>APOA1</i> gene on cognitive impairment, but not on the risk of AD." @default.
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• W2008103633 date "2007-12-10" @default.
• W2008103633 modified "2023-09-30" @default.
• W2008103633 title "An <i>Apolipoprotein A-I</i> Gene Promoter Polymorphism Associated with Cognitive Decline, but Not with Alzheimer’s Disease" @default.
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• W2008103633 doi "https://doi.org/10.1159/000112176" @default.
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