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• W2008113962 abstract "The bacterial superantigen Staphylococcal enterotoxin-A (SEA), produced by some strains of Staphylococcus aureus, causes proliferation of cytotoxic T-lymphocytes and cytokine production in vivo. SEA has been shown to be highly efficient for antibody-targeted superantegen immunotherapy for different tumor models. A candidate B-cell superantigen that has received considerable attention these days is staphylococcal protein-A (PA). It has been shown to possess multiple immunological responses. The anti-tumor property of PA is well documented in the literature in various transplantable tumors of rats and mice. In the present study, we have shown that the T-cell superantigen SEA and B-cell superantigen PA induce immunomodulatory and anti-tumor activity which is strongly protentiated by PA + SEA co-administration. Combination treatment with PA and SEA prolongs the immune response in vivo, limits the development of immunological unresponsiveness and promotes maximum anti-tumor effects to tumor carrying animals, as compared with PA or SEA alone. The immune response after combined therapy is characterized by substantially augmented IFN-gamma, TNF-alpha, Nitric oxide and strong CTL activity. Our data demonstrate that combined PA + SEA therapy induces long-term survival of the animals, carrying the Ehrlich ascites tumor." @default.
• W2008113962 created "2016-06-24" @default.
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• W2008113962 date "2002-01-01" @default.
• W2008113962 modified "2023-09-26" @default.
• W2008113962 title "REPEATED TREATMENT WITHS. AUREUSSUPERANTIGENS EXPANDS THE SURVIVAL RATE OF EHRLICH ASCITES TUMOR BEARING MICE" @default.
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• W2008113962 doi "https://doi.org/10.1081/imm-120003218" @default.
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