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- W2008114181 abstract "Ovarian tumors are formed either in the absence of Bam (bag-of-marbles) in germ-line cells or the overexpression of Dpp (decapentaplegic) in ovarian somatic cells. These tumor cells contain spectrosomes characteristic of ovarian germ-line stem cells and the immediate descendents called cystoblasts. We show that pole cells can successfully populate the gonad after transplantation to the dorsal mesoderm of host embryos following germ-band extension. By using this approach, we demonstrate that bam- cells can populate the gonad and become established as germ-line stem cells. Tumor cells containing the wild-type bam gene under heat shock transcriptional control are able to produce functional oocytes. Thus, stem cells/cystoblasts of the adult ovary are capable of forming stem cells in the embryonic ovary and recapitulating the development of the female germ line." @default.
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- W2008114181 date "2003-11-10" @default.
- W2008114181 modified "2023-10-16" @default.
- W2008114181 title "Ovarian cystocytes can repopulate the embryonic germ line and produce functional gametes" @default.
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- W2008114181 doi "https://doi.org/10.1073/pnas.2235591100" @default.
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