FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008116454> ?p ?o ?g. }

• W2008116454 endingPage "508" @default.
• W2008116454 startingPage "500" @default.
• W2008116454 abstract "The large size of the multinucleated muscle fibers of skeletal muscle makes their examination for structural and pathological defects a challenge. Sections and single fibers are accessible to antibodies and other markers but imaging of such samples does not provide a three-dimensional view of the muscle. Regrettably, bundles of fibers cannot be stained or imaged easily. Two-photon microscopy techniques overcome these obstacles. Second harmonic generation (SHG) by myosin filaments and two-photon excited fluorescence (2PEF) of mitochondrial and lysosomal components provides detailed structural information on unstained tissue. Furthermore, the infrared exciting light can penetrate several layers of muscle fibers and the minimal processing is particularly valuable for fragile biopsies. Here we demonstrate the usefulness of SHG, combined with 2PEF, to reveal enlarged lysosomes and accumulations of non-contractile material in muscles from the mouse model for the lysosomal storage disorder Pompe disease (PD), and in biopsies from adult and infant PD patients. SHG and 2PEF also detect sarcomeric defects that may presage the loss of myofibrils in atrophying muscle and signify loss of elasticity. The combination of SHG and 2PEF should be useful in the analysis and diagnosis of a wide range of skeletal muscle pathologies." @default.
• W2008116454 created "2016-06-24" @default.
• W2008116454 creator A5007107739 @default.
• W2008116454 creator A5023069185 @default.
• W2008116454 creator A5030804926 @default.
• W2008116454 creator A5035688680 @default.
• W2008116454 creator A5046731360 @default.
• W2008116454 creator A5053562667 @default.
• W2008116454 creator A5056507445 @default.
• W2008116454 creator A5058356650 @default.
• W2008116454 creator A5061131591 @default.
• W2008116454 creator A5088325650 @default.
• W2008116454 date "2008-06-01" @default.
• W2008116454 modified "2023-09-27" @default.
• W2008116454 title "Detection and imaging of non-contractile inclusions and sarcomeric anomalies in skeletal muscle by second harmonic generation combined with two-photon excited fluorescence" @default.
• W2008116454 cites W1538904872 @default.
• W2008116454 cites W1966468624 @default.
• W2008116454 cites W1971450283 @default.
• W2008116454 cites W1973406918 @default.
• W2008116454 cites W1979365820 @default.
• W2008116454 cites W1979968811 @default.
• W2008116454 cites W1985656610 @default.
• W2008116454 cites W1986149271 @default.
• W2008116454 cites W1987315996 @default.
• W2008116454 cites W1987526772 @default.
• W2008116454 cites W1996401482 @default.
• W2008116454 cites W2007891985 @default.
• W2008116454 cites W2012741951 @default.
• W2008116454 cites W2020009917 @default.
• W2008116454 cites W2023100473 @default.
• W2008116454 cites W2027886242 @default.
• W2008116454 cites W2035820080 @default.
• W2008116454 cites W2043876506 @default.
• W2008116454 cites W2053044839 @default.
• W2008116454 cites W2058025252 @default.
• W2008116454 cites W2067634317 @default.
• W2008116454 cites W2075143041 @default.
• W2008116454 cites W2076107153 @default.
• W2008116454 cites W2077458081 @default.
• W2008116454 cites W2077572701 @default.
• W2008116454 cites W2095899501 @default.
• W2008116454 cites W2097091783 @default.
• W2008116454 cites W2106592622 @default.
• W2008116454 cites W2127608615 @default.
• W2008116454 cites W2133254131 @default.
• W2008116454 cites W2151024161 @default.
• W2008116454 cites W2161841050 @default.
• W2008116454 cites W2329756551 @default.
• W2008116454 doi "https://doi.org/10.1016/j.jsb.2008.03.010" @default.
• W2008116454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2475676" @default.
• W2008116454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18468456" @default.
• W2008116454 hasPublicationYear "2008" @default.
• W2008116454 type Work @default.
• W2008116454 sameAs 2008116454 @default.
• W2008116454 citedByCount "46" @default.
• W2008116454 countsByYear W20081164542012 @default.
• W2008116454 countsByYear W20081164542013 @default.
• W2008116454 countsByYear W20081164542014 @default.
• W2008116454 countsByYear W20081164542015 @default.
• W2008116454 countsByYear W20081164542016 @default.
• W2008116454 countsByYear W20081164542017 @default.
• W2008116454 countsByYear W20081164542018 @default.
• W2008116454 countsByYear W20081164542019 @default.
• W2008116454 countsByYear W20081164542020 @default.
• W2008116454 countsByYear W20081164542023 @default.
• W2008116454 crossrefType "journal-article" @default.
• W2008116454 hasAuthorship W2008116454A5007107739 @default.
• W2008116454 hasAuthorship W2008116454A5023069185 @default.
• W2008116454 hasAuthorship W2008116454A5030804926 @default.
• W2008116454 hasAuthorship W2008116454A5035688680 @default.
• W2008116454 hasAuthorship W2008116454A5046731360 @default.
• W2008116454 hasAuthorship W2008116454A5053562667 @default.
• W2008116454 hasAuthorship W2008116454A5056507445 @default.
• W2008116454 hasAuthorship W2008116454A5058356650 @default.
• W2008116454 hasAuthorship W2008116454A5061131591 @default.
• W2008116454 hasAuthorship W2008116454A5088325650 @default.
• W2008116454 hasBestOaLocation W20081164542 @default.
• W2008116454 hasConcept C105702510 @default.
• W2008116454 hasConcept C120665830 @default.
• W2008116454 hasConcept C121332964 @default.
• W2008116454 hasConcept C12554922 @default.
• W2008116454 hasConcept C125705527 @default.
• W2008116454 hasConcept C136403682 @default.
• W2008116454 hasConcept C142724271 @default.
• W2008116454 hasConcept C147080431 @default.
• W2008116454 hasConcept C185592680 @default.
• W2008116454 hasConcept C2779959927 @default.
• W2008116454 hasConcept C30713254 @default.
• W2008116454 hasConcept C47785574 @default.
• W2008116454 hasConcept C520434653 @default.
• W2008116454 hasConcept C55493867 @default.
• W2008116454 hasConcept C6997183 @default.
• W2008116454 hasConcept C71924100 @default.
• W2008116454 hasConcept C7301908 @default.
• W2008116454 hasConcept C86803240 @default.
• W2008116454 hasConcept C91881484 @default.
• W2008116454 hasConceptScore W2008116454C105702510 @default.
• W2008116454 hasConceptScore W2008116454C120665830 @default.

• next