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- W2008122954 abstract "Tumor necrosis factor-α (TNF) is believed to be an important mediator in many diseases that are associated with the sick euthyroid syndrome. To investigate the effect of TNF on thyroid hormone linetabolism, we performed a controlled study in six healthy postabsorptive males, in whom plasma thyroid hormones and TSH were sequentially measured after iv bolus injections of recombinant human TNF (50 μg/m2) and isotonic saline. During the 10.5-h study TNF produced the characteristic changes in circulating thyroid hormones and TSH observed in the sick eiuthyroid syndrome. Compared with the control experiment, TNF induced significant decreases in T3 (−36 ± 2%; saline, −20 ± 3%; P < 0.05) and TSH levels (−68 ± 3%; saline, −44 ± 8%; P < 0.05) and a significant increase in rT3 values (+48 ± 11%; saline, −12 ± 1%; P < 0.05). T4 and free T4 index were not affected by TNF. Free T4 showed a mean transient increase of 18% in five subjects (nonsignificant), which occurred synchronically with a transient 3.5-fold rise in circulating FFA levels. Our results suggest that TNF is involved, either directly or indirectly, in the pathogenesis of the sick euthyroid syndrome." @default.
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- W2008122954 date "1990-12-01" @default.
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- W2008122954 title "Tumor Necrosis Factor: A Putative Mediator of the Sick Euthyroid Syndrome in Man*" @default.
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- W2008122954 doi "https://doi.org/10.1210/jcem-71-6-1567" @default.
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