FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008124518> ?p ?o ?g. }

• W2008124518 endingPage "326" @default.
• W2008124518 startingPage "321" @default.
• W2008124518 abstract "Using isolated perfused rabbit heart electrically paced, we assessed the relevance of both nitric oxide (NO) and prostacyclin (PGI2) in regulation of resting coronary perfusion pressure (CPP). In preparations in which NO-synthase was inhibited by NG-monomethyl-L-arginine (L-NMMA, 10 microM), resting CPP increased significantly; this phenomenon was potentiated by indomethacin infusion (3 microM), prevented by L-arginine (100 microM) and significantly reduced by iloprost (55 nM) and defibrotide (200 micrograms/ml). Furthermore, the increase in resting CPP induced by graded doses of endothelin-1 (ET-1 0.6-160 pmol), was further augmented by blocking of prostaglandin biosynthesis with indomethacin (3 microM) and was substantially reduced when the rate of formation of PGI2 was enhanced by defibrotide (200 micrograms/ml). Moreover, the coronary vasoconstriction induced by ET-1 (2, 4, and 8 pmol) was increased in hearts in which NO-synthase was blocked by L-NMMA (10 microM) and this event was abolished in preparations in which PGI2 synthesis was stimulated by defibrotide (200 micrograms/ml). These results further emphasize that rabbit coronary vessels are continuously dilated by NO released from endothelial cells. They also indicate that PGI2 takes part in NO generation in the endothelial-derived relaxing mechanism. Inactivation of this mechanism, owing to decreased formation of NO and PGI2 in rabbit heart, induces hyperreactivity of coronary smooth muscles to ET-1. Finally, an increase in PGI2 production (such as that caused by defibrotide) may counterbalance impaired NO generation and attenuate hyperreactivity of the coronary vasculature." @default.
• W2008124518 created "2016-06-24" @default.
• W2008124518 creator A5000242993 @default.
• W2008124518 creator A5018953836 @default.
• W2008124518 creator A5032227666 @default.
• W2008124518 creator A5038767012 @default.
• W2008124518 creator A5042279507 @default.
• W2008124518 creator A5055447547 @default.
• W2008124518 creator A5065366598 @default.
• W2008124518 creator A5077130421 @default.
• W2008124518 date "1993-08-01" @default.
• W2008124518 modified "2023-09-26" @default.
• W2008124518 title "Nitric Oxide and Prostacyclin Influence Coronary Vasomotor Tone in Perfused Rabbit Heart and Modulate Endothelin-1 Activity" @default.
• W2008124518 doi "https://doi.org/10.1097/00005344-199308000-00023" @default.
• W2008124518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7692176" @default.
• W2008124518 hasPublicationYear "1993" @default.
• W2008124518 type Work @default.
• W2008124518 sameAs 2008124518 @default.
• W2008124518 citedByCount "50" @default.
• W2008124518 countsByYear W20081245182013 @default.
• W2008124518 countsByYear W20081245182014 @default.
• W2008124518 countsByYear W20081245182016 @default.
• W2008124518 countsByYear W20081245182017 @default.
• W2008124518 countsByYear W20081245182021 @default.
• W2008124518 countsByYear W20081245182022 @default.
• W2008124518 crossrefType "journal-article" @default.
• W2008124518 hasAuthorship W2008124518A5000242993 @default.
• W2008124518 hasAuthorship W2008124518A5018953836 @default.
• W2008124518 hasAuthorship W2008124518A5032227666 @default.
• W2008124518 hasAuthorship W2008124518A5038767012 @default.
• W2008124518 hasAuthorship W2008124518A5042279507 @default.
• W2008124518 hasAuthorship W2008124518A5055447547 @default.
• W2008124518 hasAuthorship W2008124518A5065366598 @default.
• W2008124518 hasAuthorship W2008124518A5077130421 @default.
• W2008124518 hasBestOaLocation W20081245181 @default.
• W2008124518 hasConcept C120770815 @default.
• W2008124518 hasConcept C126322002 @default.
• W2008124518 hasConcept C134018914 @default.
• W2008124518 hasConcept C144980905 @default.
• W2008124518 hasConcept C146957229 @default.
• W2008124518 hasConcept C149601957 @default.
• W2008124518 hasConcept C170493617 @default.
• W2008124518 hasConcept C185592680 @default.
• W2008124518 hasConcept C2776992346 @default.
• W2008124518 hasConcept C2777055891 @default.
• W2008124518 hasConcept C2777408962 @default.
• W2008124518 hasConcept C2777622882 @default.
• W2008124518 hasConcept C2777712501 @default.
• W2008124518 hasConcept C2777862461 @default.
• W2008124518 hasConcept C2778165595 @default.
• W2008124518 hasConcept C2779591629 @default.
• W2008124518 hasConcept C2779961880 @default.
• W2008124518 hasConcept C2780664492 @default.
• W2008124518 hasConcept C2781103887 @default.
• W2008124518 hasConcept C2781128415 @default.
• W2008124518 hasConcept C2909649922 @default.
• W2008124518 hasConcept C2911091166 @default.
• W2008124518 hasConcept C42219234 @default.
• W2008124518 hasConcept C519581460 @default.
• W2008124518 hasConcept C71924100 @default.
• W2008124518 hasConcept C98274493 @default.
• W2008124518 hasConceptScore W2008124518C120770815 @default.
• W2008124518 hasConceptScore W2008124518C126322002 @default.
• W2008124518 hasConceptScore W2008124518C134018914 @default.
• W2008124518 hasConceptScore W2008124518C144980905 @default.
• W2008124518 hasConceptScore W2008124518C146957229 @default.
• W2008124518 hasConceptScore W2008124518C149601957 @default.
• W2008124518 hasConceptScore W2008124518C170493617 @default.
• W2008124518 hasConceptScore W2008124518C185592680 @default.
• W2008124518 hasConceptScore W2008124518C2776992346 @default.
• W2008124518 hasConceptScore W2008124518C2777055891 @default.
• W2008124518 hasConceptScore W2008124518C2777408962 @default.
• W2008124518 hasConceptScore W2008124518C2777622882 @default.
• W2008124518 hasConceptScore W2008124518C2777712501 @default.
• W2008124518 hasConceptScore W2008124518C2777862461 @default.
• W2008124518 hasConceptScore W2008124518C2778165595 @default.
• W2008124518 hasConceptScore W2008124518C2779591629 @default.
• W2008124518 hasConceptScore W2008124518C2779961880 @default.
• W2008124518 hasConceptScore W2008124518C2780664492 @default.
• W2008124518 hasConceptScore W2008124518C2781103887 @default.
• W2008124518 hasConceptScore W2008124518C2781128415 @default.
• W2008124518 hasConceptScore W2008124518C2909649922 @default.
• W2008124518 hasConceptScore W2008124518C2911091166 @default.
• W2008124518 hasConceptScore W2008124518C42219234 @default.
• W2008124518 hasConceptScore W2008124518C519581460 @default.
• W2008124518 hasConceptScore W2008124518C71924100 @default.
• W2008124518 hasConceptScore W2008124518C98274493 @default.
• W2008124518 hasIssue "2" @default.
• W2008124518 hasLocation W20081245181 @default.
• W2008124518 hasLocation W20081245182 @default.
• W2008124518 hasOpenAccess W2008124518 @default.
• W2008124518 hasPrimaryLocation W20081245181 @default.
• W2008124518 hasRelatedWork W153751066 @default.
• W2008124518 hasRelatedWork W1604615385 @default.
• W2008124518 hasRelatedWork W1969603943 @default.
• W2008124518 hasRelatedWork W1991020287 @default.
• W2008124518 hasRelatedWork W2008124518 @default.
• W2008124518 hasRelatedWork W2095416093 @default.

• next