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- W2008126023 abstract "Introduction: Human epidermal growth factor receptor (HER) 2 is overexpressed in 20 – 25% of breast cancers, and has historically been a poor prognostic marker. The introduction of trastuzumab, the first fully humanized monoclonal antibody targeting HER2, has drastically changed the outcomes of metastatic breast cancers. However, despite initial response, most patients develop resistance. Recent data suggest that strategies targeting more than one member of HER family may circumvent trastuzumab resistance and confer synergistic effects." @default.
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- W2008126023 date "2014-04-30" @default.
- W2008126023 modified "2023-10-18" @default.
- W2008126023 title "New protein kinase inhibitors in breast cancer: afatinib and neratinib" @default.
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- W2008126023 doi "https://doi.org/10.1517/14656566.2014.913570" @default.
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