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• W2008127963 abstract "A series of novel spiroisoindolines was designed and synthesized as potential noncompetitive NMDA antagonists. Affinities of these compounds for the noncompetitive NMDA binding site were determined using [3H]TCP and found to possess IC50s ranging from 0.065 to 17μM. In vivo testing of 2′-methylspiro-[4,5,6,7-tetrahydrobenzothiophene-4,1′-(1,3-dihydroisoindole)] (43) showed it to antagonize NMDA-induced convulsions, to be neuroprotective in a gerbil model of ischemia, and not to generalize to MK-801 in a drug discrimination paradigm." @default.
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• W2008127963 date "1993-01-01" @default.
• W2008127963 modified "2023-09-29" @default.
• W2008127963 title "Synthesis and activity of spiroisoindolines as novel noncompetitive NMDA antagonists" @default.
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• W2008127963 doi "https://doi.org/10.1016/s0960-894x(00)80091-8" @default.
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