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- W2008131808 abstract "Transmitter release at the first auditory synapse, the ribbon synapse of cochlear inner hair cells (IHCs), is tightly regulated by Ca2+. Using fast confocal Ca2+ imaging, we have recently described pronounced differences in presynaptic Ca2+ signals between single synapses within the same cell. These Ca2+ microdomains differed both in their amplitude and voltage-dependence of activation. As for the mechanism behind the amplitude heterogeneity, we provided indirect evidence for differences in the Ca2+ channel complement, pointing towards a differential regulation of Ca2+ channel number (NCa) across synapses. Moreover, a very simplistic model reveals potential consequences of different Ca2+ channel complements for sound encoding at different synapses In order to directly study synaptic Ca2+ channels, we are currently implementing an optical fluctuation analysis approach. Here, we present preliminary results along potential caveats. This work provides a framework of how to further dissect presynaptic Ca2+ microdomain heterogeneity - likely being involved in determining the diverse responses of the postsynaptic neurons, which, as a population, encode the huge range of perceived stimulus intensities (sound pressure varying over 6 orders of magnitude)." @default.
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- W2008131808 date "2010-01-01" @default.
- W2008131808 modified "2023-09-30" @default.
- W2008131808 title "Optical Analysis of Calcium Channels at the First Auditory Synapse" @default.
- W2008131808 doi "https://doi.org/10.1016/j.bpj.2009.12.3130" @default.
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