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• W2008138720 abstract "Abstract The synaptology of “spastic” spinal neurons, severely denervated by extensive loss of interneurons during temporary lumbosacral ischemia (which induced permanent extensor rigidity in hind limbs) was compared electron microscopically to that of neurons from same segment of the normal dog. The outstanding alteration in the surviving neurons of the operated animals consisted of a reduction in the number of receptor sites (postsynaptic thickenings) to about 25% of normal, paralleling the reduced density of axonal terminals. Postsynaptic thickenings were never observed in the absence of apposing terminals. This morphological alteration is considered a direct consequence of denervation, and it is proposed that the integrity of these postsynaptic structural specializations is dependent upon neurotrophic factors provided transneuronally by apposing synaptic terminals. Almost all of the larger terminals, found only on ventral horn neurons in normal tissue, are missing in the surviving neurons, due to mortality of intrinsic neurons whose axons project to ventral horn neurons. The mean size, size range, and size-frequency distribution of all terminals in the dorsal horn sample of the operated animals, and the density of clear vesicles within the knobs, were practically identical with those in the dorsal hron of the normal dog. The linear relationship found in the normal dog between measured synaptic contact length and diameter of synaptic knob, calculated from measured cross-sectional areas of terminals considered as spheres, was retained in the samples from operated dogs. It is suggested that the difference between the effects of denervation upon cell bodies and their dendrites on the one hand, and on the axonal extensions on the other, is related to the absence of synaptic contacts on the axonal projections and thus the axons are not directly dependent upon neurotrophic factors." @default.
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• W2008138720 date "1974-04-01" @default.
• W2008138720 modified "2023-09-24" @default.
• W2008138720 title "The receptive surface and axonal terminals in severely denervated neurons within the lumbosacral cord of the dog" @default.
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• W2008138720 doi "https://doi.org/10.1016/0014-4886(74)90139-3" @default.
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