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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008144429> ?p ?o ?g. }

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• W2008144429 abstract "The synthesis of a series of berberine, phenantridine and isoquinoline derivatives was realized to explore their Rho GTPase nucleotide inhibitory activity. The compounds were evaluated in a nucleotide binding competition assay against Rac1, Rac1b, Cdc42 and in a cellular Rac GTPase activation assay. The insertion of 19 AA in the splice variant Rac1b is shown to be sufficient to introduce a conformational difference that allows compounds 4, 21, 22, and 26 to exhibit selective inhibition of Rac 1b over Rac1." @default.
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• W2008144429 date "2009-10-01" @default.
• W2008144429 modified "2023-09-23" @default.
• W2008144429 title "Structure–activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding" @default.
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• W2008144429 doi "https://doi.org/10.1016/j.bmcl.2009.08.037" @default.
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