FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008145016> ?p ?o ?g. }

• W2008145016 endingPage "1342" @default.
• W2008145016 startingPage "1336" @default.
• W2008145016 abstract "Aim The aim of the present phase II study was to assess the antitumour activity and safety of the combination of irinotecan and carboplatin in elderly patients with small-cell lung cancer (SCLC). Material and methods Patients with previously untreated SCLC were eligible if they had a performance status of 0–2, were 70 years or older, and had adequate organ function. Patients were treated with carboplatin at an area under the plasma concentration versus time curve of 5 min/ml on day 1 and with irinotecan at 50 mg/m2 on days 1 and 8 every 3 weeks. Results Thirty patients (26 men and 4 women; median age, 76 years; age range, 70–86 years) were enrolled. Eight patients had limited disease (LD) and 22 patients had extensive disease (ED). The overall response rate was 83.3% (95% confidence interval: 65.3–94.4%). Response rates did not differ significantly between patients with LD (87.5%) and those with ED (81.8%; p = 0.71). The median survival time was 14 months overall and was significantly longer in patients with LD (26 months) than in patients with ED (11 months; p = 0.025). The median progression free survival time was 6 months overall and was significantly longer in patients with LD (12 months) than in patients with ED (6 months; p = 0.016). Grade 3–4 toxicities included neutropenia in 83% of patients, thrombocytopenia in 47%, anaemia in 60%, infection in 23%, and diarrhoea in 20%. There were no treatment-related deaths. Conclusions This chemotherapy is safe and effective for elderly patients with SCLC." @default.
• W2008145016 created "2016-06-24" @default.
• W2008145016 creator A5000850367 @default.
• W2008145016 creator A5009618044 @default.
• W2008145016 creator A5016135291 @default.
• W2008145016 creator A5027549438 @default.
• W2008145016 creator A5058813774 @default.
• W2008145016 creator A5058878517 @default.
• W2008145016 creator A5062052264 @default.
• W2008145016 creator A5073485705 @default.
• W2008145016 creator A5077367961 @default.
• W2008145016 creator A5082628144 @default.
• W2008145016 date "2011-06-01" @default.
• W2008145016 modified "2023-10-16" @default.
• W2008145016 title "Phase II trial of the combination of carboplatin and irinotecan in elderly patients with small-cell lung cancer" @default.
• W2008145016 cites W1851872955 @default.
• W2008145016 cites W1903188031 @default.
• W2008145016 cites W1912196342 @default.
• W2008145016 cites W1968483728 @default.
• W2008145016 cites W1982728538 @default.
• W2008145016 cites W1997185869 @default.
• W2008145016 cites W2005016280 @default.
• W2008145016 cites W2013123615 @default.
• W2008145016 cites W2019041562 @default.
• W2008145016 cites W2028940434 @default.
• W2008145016 cites W2042276392 @default.
• W2008145016 cites W2044746763 @default.
• W2008145016 cites W2045949627 @default.
• W2008145016 cites W2062668422 @default.
• W2008145016 cites W2073683299 @default.
• W2008145016 cites W2076643424 @default.
• W2008145016 cites W2095822339 @default.
• W2008145016 cites W2110182487 @default.
• W2008145016 cites W2113751584 @default.
• W2008145016 cites W2114699219 @default.
• W2008145016 cites W2119609623 @default.
• W2008145016 cites W2141032252 @default.
• W2008145016 cites W2141975749 @default.
• W2008145016 cites W2146589818 @default.
• W2008145016 cites W2151595445 @default.
• W2008145016 cites W2156836360 @default.
• W2008145016 cites W2160012348 @default.
• W2008145016 cites W2166418266 @default.
• W2008145016 cites W2171885026 @default.
• W2008145016 cites W2206037823 @default.
• W2008145016 cites W2323020638 @default.
• W2008145016 cites W2331849216 @default.
• W2008145016 cites W2341745217 @default.
• W2008145016 cites W2475126060 @default.
• W2008145016 doi "https://doi.org/10.1016/j.ejca.2011.03.007" @default.
• W2008145016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21458256" @default.
• W2008145016 hasPublicationYear "2011" @default.
• W2008145016 type Work @default.
• W2008145016 sameAs 2008145016 @default.
• W2008145016 citedByCount "11" @default.
• W2008145016 countsByYear W20081450162012 @default.
• W2008145016 countsByYear W20081450162013 @default.
• W2008145016 countsByYear W20081450162014 @default.
• W2008145016 countsByYear W20081450162015 @default.
• W2008145016 countsByYear W20081450162016 @default.
• W2008145016 countsByYear W20081450162017 @default.
• W2008145016 countsByYear W20081450162018 @default.
• W2008145016 countsByYear W20081450162021 @default.
• W2008145016 crossrefType "journal-article" @default.
• W2008145016 hasAuthorship W2008145016A5000850367 @default.
• W2008145016 hasAuthorship W2008145016A5009618044 @default.
• W2008145016 hasAuthorship W2008145016A5016135291 @default.
• W2008145016 hasAuthorship W2008145016A5027549438 @default.
• W2008145016 hasAuthorship W2008145016A5058813774 @default.
• W2008145016 hasAuthorship W2008145016A5058878517 @default.
• W2008145016 hasAuthorship W2008145016A5062052264 @default.
• W2008145016 hasAuthorship W2008145016A5073485705 @default.
• W2008145016 hasAuthorship W2008145016A5077367961 @default.
• W2008145016 hasAuthorship W2008145016A5082628144 @default.
• W2008145016 hasConcept C121608353 @default.
• W2008145016 hasConcept C126322002 @default.
• W2008145016 hasConcept C141071460 @default.
• W2008145016 hasConcept C2776256026 @default.
• W2008145016 hasConcept C2776694085 @default.
• W2008145016 hasConcept C2776907518 @default.
• W2008145016 hasConcept C2777063308 @default.
• W2008145016 hasConcept C2778239845 @default.
• W2008145016 hasConcept C2780259306 @default.
• W2008145016 hasConcept C2781451048 @default.
• W2008145016 hasConcept C44249647 @default.
• W2008145016 hasConcept C526805850 @default.
• W2008145016 hasConcept C71924100 @default.
• W2008145016 hasConcept C90924648 @default.
• W2008145016 hasConceptScore W2008145016C121608353 @default.
• W2008145016 hasConceptScore W2008145016C126322002 @default.
• W2008145016 hasConceptScore W2008145016C141071460 @default.
• W2008145016 hasConceptScore W2008145016C2776256026 @default.
• W2008145016 hasConceptScore W2008145016C2776694085 @default.
• W2008145016 hasConceptScore W2008145016C2776907518 @default.
• W2008145016 hasConceptScore W2008145016C2777063308 @default.
• W2008145016 hasConceptScore W2008145016C2778239845 @default.
• W2008145016 hasConceptScore W2008145016C2780259306 @default.
• W2008145016 hasConceptScore W2008145016C2781451048 @default.

• next