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- W2008150979 abstract "Objective: Disease progression and response to antiretroviral therapy (ART) in HIV-infected children is different to that of adults. Immune reconstitution in adults is mainly from memory T cells, whereas in children it occurs predominantly from the naive T-cell pool. It is unclear however what proportion of reconstituted CD4+ T cells comes from thymic export and homeostatic proliferation in the periphery. Thymic output is often estimated by measuring T-cell receptor excision circles and markers such as CD31 expressed on recent thymic emigrants but these are confounded by peripheral T-cell division and cannot in themselves be used as quantitative estimates of thymic output. Design: To compare thymic output in HIV-infected children on ART, HIV-infected children not on ART and uninfected children of different ages. Method: Combined T-cell receptor excision circle (TREC) and proliferation data are used with a recently described mathematical model to give explicit measures of thymic output. Results: We found that age-adjusted thymic output is reduced in untreated children with HIV, which increases significantly with length of time on ART. Conclusion: Our results suggest that a highly active thymus in early childhood may contribute to better immune reconstitution if ART is initiated early in life." @default.
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- W2008150979 date "2014-01-14" @default.
- W2008150979 modified "2023-10-02" @default.
- W2008150979 title "Antiretroviral therapy increases thymic output in children with HIV" @default.
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- W2008150979 doi "https://doi.org/10.1097/qad.0000000000000063" @default.
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