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• W2008154920 abstract "Male golden Syrian hamsters were evaluated as a model for the pathogenesis of human infection with Mycobacterium avium complex. Intratracheal inoculation produced a chronic, nonfatal, pulmonary and disseminated infection (overall rate, 86%). The frequency of infection in hamsters that received 5 × 108 versus 1 × 108 colony forming units (cfu) was not significantly different (87% and 92%, respectively), but 1 × 107 cfu produced infection in only 78% of inoculated animals (P = .034). The percentage of animals developing pulmonary infection with M. avium complex did not differ between inoculum groups (77%–80%). Disseminated infection occurred significantly less frequently in the 1 × 107 group (46%) compared with the 5 × 108 (79%) and 1 × 108 (68%) groups (P = .001 and .056, respectively). After seven weeks, partial clearance of M. avium complex from the lungs coincided with an increased number of animals with splenic involvement. The hamster may be a useful model for human infection with M. avium complex." @default.
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• W2008154920 date "1989-03-01" @default.
• W2008154920 modified "2023-09-27" @default.
• W2008154920 title "The Hamster Model of Chronic Mycobacterium avium Complex Infection" @default.
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• W2008154920 doi "https://doi.org/10.1093/infdis/159.3.556" @default.
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