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- W2008157439 abstract "Immune thrombocytopenic purpura ITP is characterized by early platelet destruction due to an imbalanced immune response. In acute ITP, a transient increase of HLA-DR molecules has been detected while in individuals with chronic ITP, in addition, increased serum concentrations of IL-2 and other cytokines reflecting in vivo T-cell activation have been observed. Clinically, the hemorrhagic manifestation of ITP rather than the platelet count should define the indication for active intervention. In a staging system a patient with stage III has bleeding signs and platelet counts below 10 or 20 x 10(9)/L and needs treatment, a patient with stage II should be treated on an individual level (prevention of bleeding) and a patient with stage I (no bleeding, platelet count above 50 x 10(9)/L) should be observed only." @default.
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- W2008157439 date "1998-06-01" @default.
- W2008157439 modified "2023-10-11" @default.
- W2008157439 title "Immune Thrombocytopenic Purpura ITP" @default.
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- W2008157439 doi "https://doi.org/10.1111/j.1423-0410.1998.tb05436.x" @default.
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