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- W2008157480 endingPage "137" @default.
- W2008157480 startingPage "128" @default.
- W2008157480 abstract "•Novel technological developments allow tracking of vacuolar rupture and show that more bacterial pathogens contact the host cytoplasm. •Both bacterial and host factors work together to achieve vacuole escape for most vacuole-rupturing pathogens. •Cytosolic contact elicits different host cellular responses, including autophagy and cell death. •Host cell responses to cytoplasmic bacteria have consequences for both the pathogen and the whole organism. Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens rupture their endocytic vacuoles as well as the mechanisms used to accomplish this task by bacterial species for which host cytoplasmic localization has only recently been identified. We also discuss the consequences for pathogenesis resulting from this change in intracellular localization, with a particular focus on the role of the host. What emerges is that cytoplasmic access plays an important role in the pathophysiology of an increasing number of intracellular bacterial pathogens. Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens rupture their endocytic vacuoles as well as the mechanisms used to accomplish this task by bacterial species for which host cytoplasmic localization has only recently been identified. We also discuss the consequences for pathogenesis resulting from this change in intracellular localization, with a particular focus on the role of the host. What emerges is that cytoplasmic access plays an important role in the pathophysiology of an increasing number of intracellular bacterial pathogens." @default.
- W2008157480 created "2016-06-24" @default.
- W2008157480 creator A5027674094 @default.
- W2008157480 creator A5072950637 @default.
- W2008157480 date "2014-03-01" @default.
- W2008157480 modified "2023-10-14" @default.
- W2008157480 title "Cytoplasmic access by intracellular bacterial pathogens" @default.
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