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• W2008162475 abstract "<h2>Summary</h2><h3>Objective</h3> Fluoroquinolone (FQ)-resistant <i>Mycobacterium tuberculosis</i> (MTB) clinical isolates have emerged in many areas of the world. The aim of this study was to observe the molecular characterization of <i>gyrA</i> and <i>gyrB</i> genes in FQ-resistant MTB clinical isolates from Guangdong Province in China. <h3>Materials and methods</h3> A total of 62 MTB clinical strains were originally isolated from patients with pulmonary tuberculosis. The phenotype of susceptibility of each strain was determined by the absolute concentration method and the sequences of the QRDR in <i>gyrA</i> and <i>gyrB</i> genes were detected with DNA direct sequencing technique. <h3>Results</h3> 44 of 60 (73.3%) levofloxacin-resistant MTB clinical isolates, including 17 of 18 (94.4%) high-level resistant strains and 27 of 42 (64.3%) low-level resistant strains, had mutation in QRDR of <i>gyrA</i> gene. The mutation patterns involved six patterns of single codon mutation (H70R, A90V, S91A, D94G, D94A or D94N) and one pattern of double codons mutation (A90V with D94A). Of 60 levofloxacin-resistant MTB clinical isolates, only one (1.6%) mutated in <i>gyrB</i> gene (T511N). <h3>Conclusions</h3> These findings confirm that mutations of <i>gyrA</i> codons 90, 91 and 94 constitute the primary mechanism of FQ resistance in MTB. Furthermore, our findings indicate that the regional investigations are necessary for the comprehensive understanding of FQ resistance of MTB." @default.
• W2008162475 created "2016-06-24" @default.
• W2008162475 creator A5036700493 @default.
• W2008162475 creator A5039972059 @default.
• W2008162475 date "2010-08-01" @default.
• W2008162475 modified "2023-09-24" @default.
• W2008162475 title "Mutation characterization of gyrA and gyrB genes in levofloxacin-resistant Mycobacterium tuberculosis clinical isolates from Guangdong Province in China" @default.
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• W2008162475 doi "https://doi.org/10.1016/j.jinf.2010.05.001" @default.
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