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• W2008163570 abstract "Phosphorus magnetic resonance spectroscopy is a noninvasive method to investigate brain metabolism in vivo. ATP generally serves as an internal concentration standard for the quantification of the various phosphorus metabolites, because the ATP concentration in mammalian brains is assumed to be age independent. This presumption is based on observations made in the biochemical analysis of the developing rat brain. In the present study, metabolite concentrations were assessed with an external concentration standard. Each brain spectrum was quantified using a calibration spectrum that was acquired from a phantom after the in vivo brain measurement. Fully relaxed localized brain spectra were obtained from 16 neonates (2-28 d), 17 infants (6-20 mo), and 28 adults (22-58 y). The metabolite concentrations (in mmol/L) changed from neonates to adults: phosphomonoester from 4.5 to 3.5, inorganic phosphate from 0.6 to 1.0, phosphodiester from 3.2 to 11.7, phosphocreatine from 1.4 to 3.4, and ATP from 1.6 to 2.9. We conclude that 1) the ATP concentration in the human brain almost doubles between neonates and adults, and 2) ATP may not be used as an age-independent internal concentration standard." @default.
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• W2008163570 date "1994-04-01" @default.
• W2008163570 modified "2023-10-18" @default.
• W2008163570 title "Developmental Changes of Phosphorus Metabolite Concentrations in the Human Brain: A 31P Magnetic Resonance Spectroscopy Study In Vivo" @default.
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• W2008163570 doi "https://doi.org/10.1203/00006450-199404000-00009" @default.
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