Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008165795> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2008165795 endingPage "38" @default.
- W2008165795 startingPage "35" @default.
- W2008165795 abstract "The ex vivo buccal permeability of a [d-Ala2, d-Leu5]enkephalin (DADLE) and glyceryl monooleate (GMO) was examined from the cubic and lamellar liquid crystalline phases of GMO and aqueous phosphate-buffered saline (pH 7.4, PBS) solution across excised porcine buccal mucosa mounted in a Franz cell. GMO was released in vitro from the liquid crystalline phases indicating the erosion of the liquid crystal matrices. GMO released from the liquid crystalline matrices permeated the porcine buccal mucosa with fluxes of 0.10±0.03 and 0.07±0.00%/cm2 per h for the cubic and lamellar phases, respectively. The flux of DADLE (1.21±0.32 and 1.15±0.11%/cm2 per h for the cubic and lamellar phases, respectively) from the liquid crystalline phases was significantly enhanced by the GMO compared with PBS solution (0.43±0.08%/cm2 per h) during the initial permeation phase (t<3 h). Our results suggest that the cubic and lamellar liquid crystalline phases can be considered as promising buccal drug carriers for peptide drugs as well as acting as permeation enhancers." @default.
- W2008165795 created "2016-06-24" @default.
- W2008165795 creator A5060525186 @default.
- W2008165795 creator A5089434311 @default.
- W2008165795 date "2000-02-01" @default.
- W2008165795 modified "2023-10-17" @default.
- W2008165795 title "Buccal permeation of [d-Ala2, d-Leu5]enkephalin from liquid crystalline phases of glyceryl monooleate" @default.
- W2008165795 cites W1972003319 @default.
- W2008165795 cites W1985494839 @default.
- W2008165795 cites W2093065641 @default.
- W2008165795 cites W2120168395 @default.
- W2008165795 cites W2149635167 @default.
- W2008165795 cites W2477355495 @default.
- W2008165795 cites W69451737 @default.
- W2008165795 doi "https://doi.org/10.1016/s0378-5173(99)00357-9" @default.
- W2008165795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10675680" @default.
- W2008165795 hasPublicationYear "2000" @default.
- W2008165795 type Work @default.
- W2008165795 sameAs 2008165795 @default.
- W2008165795 citedByCount "54" @default.
- W2008165795 countsByYear W20081657952012 @default.
- W2008165795 countsByYear W20081657952013 @default.
- W2008165795 countsByYear W20081657952014 @default.
- W2008165795 countsByYear W20081657952015 @default.
- W2008165795 countsByYear W20081657952016 @default.
- W2008165795 countsByYear W20081657952017 @default.
- W2008165795 countsByYear W20081657952019 @default.
- W2008165795 countsByYear W20081657952021 @default.
- W2008165795 countsByYear W20081657952023 @default.
- W2008165795 crossrefType "journal-article" @default.
- W2008165795 hasAuthorship W2008165795A5060525186 @default.
- W2008165795 hasAuthorship W2008165795A5089434311 @default.
- W2008165795 hasConcept C13274807 @default.
- W2008165795 hasConcept C170493617 @default.
- W2008165795 hasConcept C177418412 @default.
- W2008165795 hasConcept C178790620 @default.
- W2008165795 hasConcept C184651966 @default.
- W2008165795 hasConcept C185592680 @default.
- W2008165795 hasConcept C192562407 @default.
- W2008165795 hasConcept C195735259 @default.
- W2008165795 hasConcept C2777803847 @default.
- W2008165795 hasConcept C2778680407 @default.
- W2008165795 hasConcept C2781063702 @default.
- W2008165795 hasConcept C41625074 @default.
- W2008165795 hasConcept C43617362 @default.
- W2008165795 hasConcept C49040817 @default.
- W2008165795 hasConcept C50670333 @default.
- W2008165795 hasConcept C55493867 @default.
- W2008165795 hasConcept C71924100 @default.
- W2008165795 hasConcept C77851909 @default.
- W2008165795 hasConcept C8010536 @default.
- W2008165795 hasConcept C98274493 @default.
- W2008165795 hasConceptScore W2008165795C13274807 @default.
- W2008165795 hasConceptScore W2008165795C170493617 @default.
- W2008165795 hasConceptScore W2008165795C177418412 @default.
- W2008165795 hasConceptScore W2008165795C178790620 @default.
- W2008165795 hasConceptScore W2008165795C184651966 @default.
- W2008165795 hasConceptScore W2008165795C185592680 @default.
- W2008165795 hasConceptScore W2008165795C192562407 @default.
- W2008165795 hasConceptScore W2008165795C195735259 @default.
- W2008165795 hasConceptScore W2008165795C2777803847 @default.
- W2008165795 hasConceptScore W2008165795C2778680407 @default.
- W2008165795 hasConceptScore W2008165795C2781063702 @default.
- W2008165795 hasConceptScore W2008165795C41625074 @default.
- W2008165795 hasConceptScore W2008165795C43617362 @default.
- W2008165795 hasConceptScore W2008165795C49040817 @default.
- W2008165795 hasConceptScore W2008165795C50670333 @default.
- W2008165795 hasConceptScore W2008165795C55493867 @default.
- W2008165795 hasConceptScore W2008165795C71924100 @default.
- W2008165795 hasConceptScore W2008165795C77851909 @default.
- W2008165795 hasConceptScore W2008165795C8010536 @default.
- W2008165795 hasConceptScore W2008165795C98274493 @default.
- W2008165795 hasIssue "1-2" @default.
- W2008165795 hasLocation W20081657951 @default.
- W2008165795 hasLocation W20081657952 @default.
- W2008165795 hasOpenAccess W2008165795 @default.
- W2008165795 hasPrimaryLocation W20081657951 @default.
- W2008165795 hasRelatedWork W1971627098 @default.
- W2008165795 hasRelatedWork W1983355973 @default.
- W2008165795 hasRelatedWork W1998593427 @default.
- W2008165795 hasRelatedWork W2033770595 @default.
- W2008165795 hasRelatedWork W2073775123 @default.
- W2008165795 hasRelatedWork W2083114813 @default.
- W2008165795 hasRelatedWork W2083486989 @default.
- W2008165795 hasRelatedWork W2263735244 @default.
- W2008165795 hasRelatedWork W2270026187 @default.
- W2008165795 hasRelatedWork W2294495386 @default.
- W2008165795 hasVolume "195" @default.
- W2008165795 isParatext "false" @default.
- W2008165795 isRetracted "false" @default.
- W2008165795 magId "2008165795" @default.
- W2008165795 workType "article" @default.