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- W2008165989 abstract "Abstract The effects of protein concentration and heat-stabilization time at 120 ° C on the release rate of adriamycin from microspheres have been investigated. The albumin concentration and the stabilization time of the microspheres were varied from 20 to 40% w/v and from 2.5 to 10 min, respectively. The release studies carried out using dynamic dialysis demonstrated that irrespective of the protein concentration and stabilization time, the initial release rate was significantly higher than the terminal release rate of adriamycin from these particles. Whereas variation in the albumin concentration was shown to cause comparable changes in the initial and the terminal release rate constants of adriamycin, the variation in the stabilization time predominantly affected the terminal release rate constants. The results indicate that protein concentration as well as the heat-stabilization time of albumin microspheres may be used to control the release of entrapped drug." @default.
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- W2008165989 date "1989-05-01" @default.
- W2008165989 modified "2023-09-24" @default.
- W2008165989 title "Albumin microspheres. IV. Effect of protein concentration and stabilization time on the release rate of adriamycin" @default.
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- W2008165989 doi "https://doi.org/10.1016/0378-5173(89)90199-3" @default.
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