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- W2008173615 abstract "Genomic instability is a hallmark of cancer cells, and arises from the aberrations that these cells exhibit in the normal biological mechanisms that repair and replicate the genome, or ensure its accurate segregation during cell division. Increasingly detailed descriptions of cancer genomes have begun to emerge from next-generation sequencing (NGS), providing snapshots of their nature and heterogeneity in different cancers at different stages in their evolution. Here, we attempt to extract from these sequencing studies insights into the role of genome instability mechanisms in carcinogenesis, and to identify challenges impeding further progress." @default.
- W2008173615 created "2016-06-24" @default.
- W2008173615 creator A5026575963 @default.
- W2008173615 creator A5030931491 @default.
- W2008173615 date "2012-02-01" @default.
- W2008173615 modified "2023-09-26" @default.
- W2008173615 title "Genome instability mechanisms and the structure of cancer genomes" @default.
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- W2008173615 doi "https://doi.org/10.1016/j.gde.2012.02.003" @default.
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