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- W2008177768 abstract "Abstract The relationship of anoxemia of the auricles and vagal stimulation (mecholyl effect) was investigated in the hearts of dogs. In the normally beating heart it was found that: (1) anoxemia apparently renders the heart more sensitive to the action of mecholyl; (2) auricular fibrillation frequently occurs spontaneously, or is easily induced by minute, mechanical, auricular stimuli after small doses of mecholyl during anoxemia; (3) reoxygenation of the blood results in the restoration of normal cardiac mechanism. In another series of experiments, the factor of auricular distension was eliminated by perfusing the coronary vessels of the heart while the heart was beating empty; the administration of mecholyl during perfusion with anoxic blood produced auricular fibrillation. Mecholyl also produced auricular fibrillation in hearts with acute, experimental “mitral stenosis.” The possible mechanisms by which auricular anoxemia, together with the action of mecholyl, may precipitate atrial fibrillation are discussed, and the clinical aspects considered." @default.
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- W2008177768 date "1944-02-01" @default.
- W2008177768 modified "2023-09-27" @default.
- W2008177768 title "Studies on the production and maintenance of experimental auricular fibrillation" @default.
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- W2008177768 doi "https://doi.org/10.1016/s0002-8703(44)90723-4" @default.
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