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- W2008178150 abstract "Minocycline, a semisynthetic derivative of tetracycline that is used in the long-term treatment of many disorders, has been shown to occasionally cause a disfiguring cutaneous hyperpigmentation that may persist years after cessation of therapy.<sup>1-3</sup>To date, the precise mechanism of minocycline-induced cutaneous hyperpigmentation has not been fully elucidated; however, various histopathologic studies suggest that iron deposition,<sup>1-5</sup>increased melanization,<sup>2,3,5</sup>and/or deposits of minocycline degradation byproducts<sup>1,2,5,6</sup>may be associated with this condition. The Q-switched ruby laser, which operates under the principle of selective photothermolysis at 694 nm, effectively targets melanocytic and blue-black chromophores with minimal disruption of surrounding cutaneous structures and has been successfully used in the treatment of a variety of lesions characterized by dense deposits of dark pigments. We evaluated the efficacy of the Q-switched ruby laser in the treatment of persistent minocycline-induced hyperpigmentation associated with increased melanization. <h3>Report of a Case.</h3> A 59-year-old white woman" @default.
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- W2008178150 date "1996-10-01" @default.
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- W2008178150 title "Q-Switched Ruby Laser Treatment of Minocycline-Induced Cutaneous Hyperpigmentation" @default.
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- W2008178150 doi "https://doi.org/10.1001/archderm.1996.03890340117026" @default.
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