FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008183758> ?p ?o ?g. }

• W2008183758 endingPage "1860" @default.
• W2008183758 startingPage "1853" @default.
• W2008183758 abstract "Fangchinoline (FAN; a plant alkaloid isolated from Stephania tetrandrae) is a nonspecific Ca(2+) channel blocker. The objective of the present study was to investigate the effect of FAN on the growth factor-induced proliferation of primary cultured rat aortic smooth muscle cells (RASMCs). FAN significantly inhibited both 5% fetal bovine serum (FBS)- and 50ng/mL platelet-derived growth factor (PDGF)-BB-induced proliferation, [3H]thymidine incorporation into DNA and phosphorylation of extracellular signal-regulated kinase 1/2. In accordance with these findings, FAN revealed blocking of the FBS-inducible progression through G(0)/G(1) to S phase of the cell cycle in synchronized cells and caused a 62% decrease in the early elevation of c-fos expression induced after 5% FBS addition. Furthermore, significant antiproliferative activity of FAN is observed at concentrations below those required to achieve significant inhibition of Ca(2+) channels by FAN. These results suggest that FAN reduced both FBS- and PDGF-BB-induced RASMCs proliferation by perturbing cell cycle progression. This antiproliferative effect of FAN is dependent on the MAP kinase pathway, but cannot be limited to its Ca(2+) modulation." @default.
• W2008183758 created "2016-06-24" @default.
• W2008183758 creator A5026299521 @default.
• W2008183758 creator A5062757978 @default.
• W2008183758 creator A5071698217 @default.
• W2008183758 date "2003-11-01" @default.
• W2008183758 modified "2023-10-16" @default.
• W2008183758 title "Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression" @default.
• W2008183758 cites W1512900448 @default.
• W2008183758 cites W1573821584 @default.
• W2008183758 cites W1969115332 @default.
• W2008183758 cites W1971334343 @default.
• W2008183758 cites W1978038878 @default.
• W2008183758 cites W1988626066 @default.
• W2008183758 cites W1991389550 @default.
• W2008183758 cites W1992472345 @default.
• W2008183758 cites W1999157780 @default.
• W2008183758 cites W1999983218 @default.
• W2008183758 cites W2004186357 @default.
• W2008183758 cites W2016211156 @default.
• W2008183758 cites W2034657077 @default.
• W2008183758 cites W2050809217 @default.
• W2008183758 cites W2063419308 @default.
• W2008183758 cites W2074878991 @default.
• W2008183758 cites W2082452955 @default.
• W2008183758 cites W2087822630 @default.
• W2008183758 cites W2088522547 @default.
• W2008183758 cites W2103382643 @default.
• W2008183758 cites W2137570167 @default.
• W2008183758 cites W2140626372 @default.
• W2008183758 cites W4293247451 @default.
• W2008183758 doi "https://doi.org/10.1016/s0006-2952(03)00550-1" @default.
• W2008183758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14563495" @default.
• W2008183758 hasPublicationYear "2003" @default.
• W2008183758 type Work @default.
• W2008183758 sameAs 2008183758 @default.
• W2008183758 citedByCount "24" @default.
• W2008183758 countsByYear W20081837582012 @default.
• W2008183758 countsByYear W20081837582013 @default.
• W2008183758 countsByYear W20081837582014 @default.
• W2008183758 countsByYear W20081837582015 @default.
• W2008183758 countsByYear W20081837582018 @default.
• W2008183758 crossrefType "journal-article" @default.
• W2008183758 hasAuthorship W2008183758A5026299521 @default.
• W2008183758 hasAuthorship W2008183758A5062757978 @default.
• W2008183758 hasAuthorship W2008183758A5071698217 @default.
• W2008183758 hasConcept C126322002 @default.
• W2008183758 hasConcept C134018914 @default.
• W2008183758 hasConcept C1491633281 @default.
• W2008183758 hasConcept C153911025 @default.
• W2008183758 hasConcept C170493617 @default.
• W2008183758 hasConcept C180361614 @default.
• W2008183758 hasConcept C202751555 @default.
• W2008183758 hasConcept C2775960820 @default.
• W2008183758 hasConcept C2779395532 @default.
• W2008183758 hasConcept C2779404806 @default.
• W2008183758 hasConcept C2781294074 @default.
• W2008183758 hasConcept C28406088 @default.
• W2008183758 hasConcept C29537977 @default.
• W2008183758 hasConcept C2992686903 @default.
• W2008183758 hasConcept C54355233 @default.
• W2008183758 hasConcept C55493867 @default.
• W2008183758 hasConcept C62112901 @default.
• W2008183758 hasConcept C64241487 @default.
• W2008183758 hasConcept C71924100 @default.
• W2008183758 hasConcept C81885089 @default.
• W2008183758 hasConcept C86803240 @default.
• W2008183758 hasConcept C95444343 @default.
• W2008183758 hasConceptScore W2008183758C126322002 @default.
• W2008183758 hasConceptScore W2008183758C134018914 @default.
• W2008183758 hasConceptScore W2008183758C1491633281 @default.
• W2008183758 hasConceptScore W2008183758C153911025 @default.
• W2008183758 hasConceptScore W2008183758C170493617 @default.
• W2008183758 hasConceptScore W2008183758C180361614 @default.
• W2008183758 hasConceptScore W2008183758C202751555 @default.
• W2008183758 hasConceptScore W2008183758C2775960820 @default.
• W2008183758 hasConceptScore W2008183758C2779395532 @default.
• W2008183758 hasConceptScore W2008183758C2779404806 @default.
• W2008183758 hasConceptScore W2008183758C2781294074 @default.
• W2008183758 hasConceptScore W2008183758C28406088 @default.
• W2008183758 hasConceptScore W2008183758C29537977 @default.
• W2008183758 hasConceptScore W2008183758C2992686903 @default.
• W2008183758 hasConceptScore W2008183758C54355233 @default.
• W2008183758 hasConceptScore W2008183758C55493867 @default.
• W2008183758 hasConceptScore W2008183758C62112901 @default.
• W2008183758 hasConceptScore W2008183758C64241487 @default.
• W2008183758 hasConceptScore W2008183758C71924100 @default.
• W2008183758 hasConceptScore W2008183758C81885089 @default.
• W2008183758 hasConceptScore W2008183758C86803240 @default.
• W2008183758 hasConceptScore W2008183758C95444343 @default.
• W2008183758 hasIssue "9" @default.
• W2008183758 hasLocation W20081837581 @default.
• W2008183758 hasLocation W20081837582 @default.
• W2008183758 hasOpenAccess W2008183758 @default.
• W2008183758 hasPrimaryLocation W20081837581 @default.
• W2008183758 hasRelatedWork W2027647801 @default.
• W2008183758 hasRelatedWork W2041962609 @default.
• W2008183758 hasRelatedWork W2064061791 @default.

• next