FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008187488> ?p ?o ?g. }

• W2008187488 endingPage "H1643" @default.
• W2008187488 startingPage "H1631" @default.
• W2008187488 abstract "The current study examined the role of Na/K-ATPase α1-subunit in animals subjected to 5/6th partial nephrectomy (PNx) using Na/K-ATPase α1-heterozygous (α1(+/-)) mice and their wild-type (WT) littermates. After PNx, both WT and α1(+/-) animals displayed diastolic dimension increases, increased blood pressure, and increased cardiac hypertrophy. However, in the α1(+/-) animals we detected significant increases in cardiac cell death in PNx animals. Given that reduction of α1 elicited increased cardiac cell death with PNx, while at the same time these animals developed cardiac hypertrophy, an examination of cardiac cell number, and proliferative capabilities of those cells was carried out. Cardiac tissues were probed for the progenitor cell marker c-kit and the proliferation marker ki-67. The results revealed that α1(+/-) mice had significantly higher numbers of c-kit-positive and ki-67-positive cells, especially in the PNx group. We also found that α1(+/-) mice express higher levels of stem cell factor, a c-kit ligand, in their heart tissue and had higher circulating levels of stem cell factor than WT animals. In addition, PNx induced significant enlargement of cardiac myocytes in WT mice but has much less effect in α1(+/-) mice. However, the total cell number determined by nuclear counting is higher in α1(+/-) mice with PNx compared with WT mice. We conclude that PNx induces hypertrophic growth and high blood pressure regardless of Na/K-ATPase content change. However, total cardiac cell number as well as c-kit-positive cell number is increased in α1(+/-) mice with PNx." @default.
• W2008187488 created "2016-06-24" @default.
• W2008187488 creator A5004658590 @default.
• W2008187488 creator A5016178402 @default.
• W2008187488 creator A5025749942 @default.
• W2008187488 creator A5030899889 @default.
• W2008187488 creator A5031874278 @default.
• W2008187488 creator A5038688992 @default.
• W2008187488 creator A5066033680 @default.
• W2008187488 creator A5077735587 @default.
• W2008187488 creator A5079259073 @default.
• W2008187488 creator A5080237153 @default.
• W2008187488 creator A5085336308 @default.
• W2008187488 date "2014-06-15" @default.
• W2008187488 modified "2023-09-30" @default.
• W2008187488 title "Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice" @default.
• W2008187488 cites W1777419882 @default.
• W2008187488 cites W1964265264 @default.
• W2008187488 cites W1970448985 @default.
• W2008187488 cites W1970953376 @default.
• W2008187488 cites W1974140987 @default.
• W2008187488 cites W1977043280 @default.
• W2008187488 cites W1996510966 @default.
• W2008187488 cites W1996698106 @default.
• W2008187488 cites W1997882924 @default.
• W2008187488 cites W2008016893 @default.
• W2008187488 cites W2008688200 @default.
• W2008187488 cites W2014259599 @default.
• W2008187488 cites W2017324812 @default.
• W2008187488 cites W2022147892 @default.
• W2008187488 cites W2024466754 @default.
• W2008187488 cites W2028036560 @default.
• W2008187488 cites W2031517092 @default.
• W2008187488 cites W2036525653 @default.
• W2008187488 cites W2044887661 @default.
• W2008187488 cites W2049161368 @default.
• W2008187488 cites W2050988292 @default.
• W2008187488 cites W2055323054 @default.
• W2008187488 cites W2056814323 @default.
• W2008187488 cites W2061569406 @default.
• W2008187488 cites W2065171831 @default.
• W2008187488 cites W2067591094 @default.
• W2008187488 cites W2081787890 @default.
• W2008187488 cites W2093494581 @default.
• W2008187488 cites W2096904076 @default.
• W2008187488 cites W2101467963 @default.
• W2008187488 cites W2102161478 @default.
• W2008187488 cites W2107703251 @default.
• W2008187488 cites W2108650851 @default.
• W2008187488 cites W2113784050 @default.
• W2008187488 cites W2114222046 @default.
• W2008187488 cites W2117870093 @default.
• W2008187488 cites W2119379108 @default.
• W2008187488 cites W2128995496 @default.
• W2008187488 cites W2132689936 @default.
• W2008187488 cites W2132735690 @default.
• W2008187488 cites W2134113483 @default.
• W2008187488 cites W2134912211 @default.
• W2008187488 cites W2143617499 @default.
• W2008187488 cites W2144327104 @default.
• W2008187488 cites W2151617426 @default.
• W2008187488 cites W2156800444 @default.
• W2008187488 cites W2158682140 @default.
• W2008187488 cites W2159904330 @default.
• W2008187488 cites W2162807458 @default.
• W2008187488 cites W2165389287 @default.
• W2008187488 cites W2168769990 @default.
• W2008187488 cites W2270719279 @default.
• W2008187488 doi "https://doi.org/10.1152/ajpheart.00102.2014" @default.
• W2008187488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4059984" @default.
• W2008187488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24748592" @default.
• W2008187488 hasPublicationYear "2014" @default.
• W2008187488 type Work @default.
• W2008187488 sameAs 2008187488 @default.
• W2008187488 citedByCount "21" @default.
• W2008187488 countsByYear W20081874882015 @default.
• W2008187488 countsByYear W20081874882016 @default.
• W2008187488 countsByYear W20081874882017 @default.
• W2008187488 countsByYear W20081874882018 @default.
• W2008187488 countsByYear W20081874882019 @default.
• W2008187488 countsByYear W20081874882020 @default.
• W2008187488 countsByYear W20081874882021 @default.
• W2008187488 countsByYear W20081874882022 @default.
• W2008187488 crossrefType "journal-article" @default.
• W2008187488 hasAuthorship W2008187488A5004658590 @default.
• W2008187488 hasAuthorship W2008187488A5016178402 @default.
• W2008187488 hasAuthorship W2008187488A5025749942 @default.
• W2008187488 hasAuthorship W2008187488A5030899889 @default.
• W2008187488 hasAuthorship W2008187488A5031874278 @default.
• W2008187488 hasAuthorship W2008187488A5038688992 @default.
• W2008187488 hasAuthorship W2008187488A5066033680 @default.
• W2008187488 hasAuthorship W2008187488A5077735587 @default.
• W2008187488 hasAuthorship W2008187488A5079259073 @default.
• W2008187488 hasAuthorship W2008187488A5080237153 @default.
• W2008187488 hasAuthorship W2008187488A5085336308 @default.
• W2008187488 hasBestOaLocation W20081874882 @default.
• W2008187488 hasConcept C126322002 @default.
• W2008187488 hasConcept C134018914 @default.

• next