Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008200538> ?p ?o ?g. }
- W2008200538 abstract "Fertilisation is an orchestrated, stepwise process during which the participating male and female gametes undergo irreversible changes, losing some of their structural components while contributing others to the resultant zygote. Following sperm penetration through the egg coat, the sperm plasma membrane fuses with its oocyte counterpart, the oolemma. At least two plasma membrane proteins essential for sperm–oolemma fusion – IZUMO and CD9 on the male and female gametes, respectively – have been identified recently by classical cell biology approaches and confirmed by gene deletion. Oolemma-associated tetraspanin CD81, closely related to CD9, also appears to have an essential role in fusion. Additional proteins that may have nonessential yet still facilitating roles in sperm–oolemma adhesion and fusion include oolemma-anchored integrins and oocyte-expressed retroviral envelope proteins, sperm disintegrins, and sperm-borne proteins of epididymal origin such as CRISP1 and CRISP2. This review discusses these components of the gamete fusion mechanism within the framework of gamete structure, membrane biology, cell signalling and cytoskeletal dynamics, and revisits the topic of antipolyspermy defence at the oolemma level. Harnessing the mechanisms of sperm–egg fusion is of importance to animal biotechnology and to human assisted fertilisation, wherein male patients with reduced sperm fusibility have been identified." @default.
- W2008200538 created "2016-06-24" @default.
- W2008200538 creator A5034305224 @default.
- W2008200538 date "2009-04-01" @default.
- W2008200538 modified "2023-10-03" @default.
- W2008200538 title "Sperm–egg adhesion and fusion in mammals" @default.
- W2008200538 cites W105272822 @default.
- W2008200538 cites W1506921048 @default.
- W2008200538 cites W1517312396 @default.
- W2008200538 cites W1929719444 @default.
- W2008200538 cites W1965600804 @default.
- W2008200538 cites W1968574939 @default.
- W2008200538 cites W1969612920 @default.
- W2008200538 cites W1969939987 @default.
- W2008200538 cites W1971430155 @default.
- W2008200538 cites W1972028138 @default.
- W2008200538 cites W1974130663 @default.
- W2008200538 cites W1975898667 @default.
- W2008200538 cites W1977656954 @default.
- W2008200538 cites W1981617710 @default.
- W2008200538 cites W1985599438 @default.
- W2008200538 cites W1989033643 @default.
- W2008200538 cites W1995822948 @default.
- W2008200538 cites W1996931717 @default.
- W2008200538 cites W1996983058 @default.
- W2008200538 cites W1998401946 @default.
- W2008200538 cites W2009408340 @default.
- W2008200538 cites W2013078329 @default.
- W2008200538 cites W2013898345 @default.
- W2008200538 cites W2016605627 @default.
- W2008200538 cites W2019554538 @default.
- W2008200538 cites W2019815668 @default.
- W2008200538 cites W2020541161 @default.
- W2008200538 cites W2021121382 @default.
- W2008200538 cites W2029866797 @default.
- W2008200538 cites W2035843184 @default.
- W2008200538 cites W2040942099 @default.
- W2008200538 cites W2048588885 @default.
- W2008200538 cites W2057036500 @default.
- W2008200538 cites W2058485556 @default.
- W2008200538 cites W2060234220 @default.
- W2008200538 cites W2062886903 @default.
- W2008200538 cites W2073961859 @default.
- W2008200538 cites W2074395223 @default.
- W2008200538 cites W2078286807 @default.
- W2008200538 cites W2080203763 @default.
- W2008200538 cites W2083660146 @default.
- W2008200538 cites W2083702073 @default.
- W2008200538 cites W2085077505 @default.
- W2008200538 cites W2086220467 @default.
- W2008200538 cites W2087094729 @default.
- W2008200538 cites W2087645253 @default.
- W2008200538 cites W2089003364 @default.
- W2008200538 cites W2090025235 @default.
- W2008200538 cites W2090282166 @default.
- W2008200538 cites W2093538523 @default.
- W2008200538 cites W2094675705 @default.
- W2008200538 cites W2096025413 @default.
- W2008200538 cites W2098744542 @default.
- W2008200538 cites W2099028749 @default.
- W2008200538 cites W2105299356 @default.
- W2008200538 cites W2108449887 @default.
- W2008200538 cites W2108463852 @default.
- W2008200538 cites W2116472416 @default.
- W2008200538 cites W2117241641 @default.
- W2008200538 cites W2118881578 @default.
- W2008200538 cites W2119118605 @default.
- W2008200538 cites W2120107461 @default.
- W2008200538 cites W2121281020 @default.
- W2008200538 cites W2124305007 @default.
- W2008200538 cites W2127825189 @default.
- W2008200538 cites W2132599637 @default.
- W2008200538 cites W2133594770 @default.
- W2008200538 cites W2134477053 @default.
- W2008200538 cites W2135370248 @default.
- W2008200538 cites W2135782435 @default.
- W2008200538 cites W2138734315 @default.
- W2008200538 cites W2142563211 @default.
- W2008200538 cites W2150123812 @default.
- W2008200538 cites W2150322957 @default.
- W2008200538 cites W2153344238 @default.
- W2008200538 cites W2156278032 @default.
- W2008200538 cites W2164070738 @default.
- W2008200538 cites W2168108725 @default.
- W2008200538 cites W2185450801 @default.
- W2008200538 cites W2336731832 @default.
- W2008200538 cites W2395974956 @default.
- W2008200538 cites W2400395707 @default.
- W2008200538 cites W2415893569 @default.
- W2008200538 doi "https://doi.org/10.1017/s1462399409001045" @default.
- W2008200538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19335925" @default.
- W2008200538 hasPublicationYear "2009" @default.
- W2008200538 type Work @default.
- W2008200538 sameAs 2008200538 @default.
- W2008200538 citedByCount "58" @default.
- W2008200538 countsByYear W20082005382012 @default.
- W2008200538 countsByYear W20082005382013 @default.
- W2008200538 countsByYear W20082005382014 @default.
- W2008200538 countsByYear W20082005382015 @default.
- W2008200538 countsByYear W20082005382016 @default.