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- W2008201148 abstract "The inducible human cationic amino acid transporter hCAT-2B was expressed inXenopus laevisoocytes, and this system was used to test the effect of several NO synthase (NOS) inhibitors and/orL-arginine analogues onL-arginine transport by this y+carrier.L-NG-Methyl-L-arginine (L-NMA), asymmetricalL-NG,NG-dimethyl-L-arginine (L-ADMA),L-N5-(1-iminoethyl)-ornithine (L-NIO),L-NG-nitro-L-arginine (L-NNA), andL-NG-nitro-L-arginine methyl ester (L-NAME) all inhibited the inducible NOS II extracted from RAW 264.7 macrophages induced with bacterial lipopolysaccharide. L-NMA, L-ADMA, and L-NIO also competed withL-arginine for transport by hCAT-2B, whereas L-NNA and L-NAME did not. The twoL-arginine analogues, symmetricalNG,N′-dimethyl-L-arginine (L-SDMA) and α-amino-δ-isothioureidovaleric acid (AITV), as well asL-lysine, did not block enzymatic activity of NOS II, but did compete forL-arginine transport mediated by hCAT-2B.L-Lysine and L-SDMA were transported efficiently by hCAT-2B and exchanged against intracellularL-arginine, resulting in anL-arginine depletion of the cells. AITV was a much poorer substrate of hCAT-2B and had only little effect on intracellularL-arginine concentrations. These data indicate that substrate recognition differs markedly between the inducibleL-arginine transporter hCAT-2B and the inducible NOS II, with differentL-arginine analogues having affinity to only one or both of these proteins." @default.
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- W2008201148 date "1997-02-01" @default.
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- W2008201148 title "Interference ofL-Arginine Analogues withL-Arginine Transport Mediated by the y+Carrier hCAT-2B" @default.
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- W2008201148 doi "https://doi.org/10.1006/niox.1996.0106" @default.
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