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• W2008201895 abstract "Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Parkin might function in concert to modulate mitochondrial degradation, termed mitophagy. However, the molecular mechanisms by which PINK1/Parkin affect mitophagy are just beginning to be elucidated. Herein, we review the main advances in our understanding of the PINK1/Parkin pathway. Because of the phenotypic similarities among the different forms of PD, a better understanding of PINK1/Parkin biology might have far-reaching pathogenic and therapeutic implications for both the inherited and the sporadic forms of PD. Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Parkin might function in concert to modulate mitochondrial degradation, termed mitophagy. However, the molecular mechanisms by which PINK1/Parkin affect mitophagy are just beginning to be elucidated. Herein, we review the main advances in our understanding of the PINK1/Parkin pathway. Because of the phenotypic similarities among the different forms of PD, a better understanding of PINK1/Parkin biology might have far-reaching pathogenic and therapeutic implications for both the inherited and the sporadic forms of PD." @default.
• W2008201895 created "2016-06-24" @default.
• W2008201895 creator A5057571524 @default.
• W2008201895 creator A5091172439 @default.
• W2008201895 date "2011-03-01" @default.
• W2008201895 modified "2023-10-18" @default.
• W2008201895 title "Mitophagy: the latest problem for Parkinson's disease" @default.
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• W2008201895 doi "https://doi.org/10.1016/j.molmed.2010.11.002" @default.
• W2008201895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21146459" @default.
• W2008201895 hasPublicationYear "2011" @default.
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