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- W2008202004 abstract "Co-stimulatory molecules play an important role in initiating antitumor immune responses. Engineered tumor cells expressing co-stimulatory molecules have been used as cancer vaccines in both experimental tumor models and clinical trials. In this study, we cloned a cDNA gene coding for the mouse co-stimulatory molecule 4-1BBL by RTPCR. The expression vector pCI-4-1BBL was constructed by DNA recombinant technology and further transfected into a moderately immunogenic EL4 and a poorly immunogenic BL6-10 tumor cell line. Expression of the co-stimulatory molecule 4-1BBL is able to induce tumor regression of EL4/4-1BBL but not BL6-10/4-1BBL tumor cell line in syngeneic BALB/c mice. The tumor regression which is mainly mediated by CD8+ T cells further leads to protective immunity against the parental EL4 tumor. Our results thus indicate the potential utility of engineered tumor cells expressing co-stimulatory molecule 4-1BBL, especially in combination with other co-stimulatory molecules such as B7-1 in cancer vaccine." @default.
- W2008202004 created "2016-06-24" @default.
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- W2008202004 date "1999-10-01" @default.
- W2008202004 modified "2023-09-23" @default.
- W2008202004 title "Expression of Co-stimulatory 4-1BB Ligand Induces Significant Tumor Regression and Protective Immunity" @default.
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- W2008202004 doi "https://doi.org/10.1089/cbr.1999.14.353" @default.
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