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- W2008202224 abstract "Three pharmacological agents (disulfiram, imipramine and reserpine) influencing the brain monoamine transmitters have been studied to explain the mechanism involved in the motor circadian rhythm.The new results corroborate our previous ones : the norepinephrine transmitter responsible for the paradoxical sleep is unable to explain the depressed metabolic phase of the circadian rhythm; the negative results obtained with disulfiram and imipramine corroborate the previous results with nialamide.On the contrary, the agents which reduce the serotonine transmitter mechanisms (p-chlorophenylalanine) decrease the difference between active and sleep phases by their action involved in the non-activated sleep. Reserpine, supposed to reduce both transmitter mechanisms (serotonine and norepinephrine) shows a p-chlorophenylalanine-like effect, perhaps more strong. It thus appears that the non-activated sleep is responsible for the two essential sleep functions : the restitution function and the depressed phase of the circadian rhythm." @default.
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- W2008202224 date "1978-01-01" @default.
- W2008202224 modified "2023-09-25" @default.
- W2008202224 title "Analyse du Rythme Circadien de L'Activite Motrice du Rat Blanc Par L'Emploi de Plusieurs Agents Pharmacologiques Agissant Sur Les Monoamines Cérébrales" @default.
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- W2008202224 doi "https://doi.org/10.3109/13813457809055965" @default.
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