Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008205989> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2008205989 endingPage "749" @default.
- W2008205989 startingPage "744" @default.
- W2008205989 abstract "Evolution by gene duplication and subsequent divergence is indicated by similarities common to 43 different transfer RNAs. Pairwise comparisons of these tRNAs reveal additional similarity, greatest for certain pairs of tRNAs for the same amino acid in the same organism, and also occurring in certain pairs of tRNAs for different amino acids in the same organism. Although tRNAs functionally interact with several other molecules, there have been surprisingly few restrictions on the divergence of their primary structures. This divergence has proceeded so far that clear phylogenetic separations are absent in most cases: it it impossible to construct a coherent phylogeny for most of the 43. Selection and stochastic processes have both been active in the evolution of tRNA. Selection has favored moderate change more than expected and has reduced radical change below that expected from stochastic processes alone. Two obvious effects of selection are nine invariant loci, another five that are always purines and five others that are always pyrimidines, in the tRNAs involved in protein synthesis. In addition to these constraints in the primary nucleotide sequence, the method of “identical site equivalents”, introduced here, demonstrates that further constraints exist equivalent to about 12 additional invariant loci. These “invisible” restraints reflect disperse chemical forces maintaining the tertiary structure and reducing evolutionary divergence to an extent quantitatively comparable to that of the nine observable invariant loci. The average divergence (49·4%) for pairs of tRNAs for different amino acids involved in protein synthesis represents an equilibrium between natural selection and stochastic processes. These tRNAs have had time to diverge nearly to the 75% maximum expected from stochastic process alone; this is shown by comparing the two glycine tRNAs involved in peptidoglycan synthesis with tRNAs for different amino acids participating in polypeptide synthesis. The rates of nucleotide replacements in genes coding for the tRNAs and the cytochromes c are about the same: 2 × 10 −10 replacements per nucleotide site per year." @default.
- W2008205989 created "2016-06-24" @default.
- W2008205989 creator A5078279990 @default.
- W2008205989 date "1966-09-01" @default.
- W2008205989 modified "2023-10-16" @default.
- W2008205989 title "Indications for a common evolutionary origin shown in the primary structure of three transfer RNAs" @default.
- W2008205989 cites W1594574235 @default.
- W2008205989 cites W1989687791 @default.
- W2008205989 cites W2024412145 @default.
- W2008205989 cites W2076599992 @default.
- W2008205989 cites W2158948173 @default.
- W2008205989 cites W2314809577 @default.
- W2008205989 doi "https://doi.org/10.1016/0006-291x(66)90388-3" @default.
- W2008205989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5970507" @default.
- W2008205989 hasPublicationYear "1966" @default.
- W2008205989 type Work @default.
- W2008205989 sameAs 2008205989 @default.
- W2008205989 citedByCount "15" @default.
- W2008205989 crossrefType "journal-article" @default.
- W2008205989 hasAuthorship W2008205989A5078279990 @default.
- W2008205989 hasConcept C104317684 @default.
- W2008205989 hasConcept C105795698 @default.
- W2008205989 hasConcept C10853874 @default.
- W2008205989 hasConcept C153957851 @default.
- W2008205989 hasConcept C154945302 @default.
- W2008205989 hasConcept C184898388 @default.
- W2008205989 hasConcept C193252679 @default.
- W2008205989 hasConcept C33923547 @default.
- W2008205989 hasConcept C41008148 @default.
- W2008205989 hasConcept C515207424 @default.
- W2008205989 hasConcept C54355233 @default.
- W2008205989 hasConcept C67705224 @default.
- W2008205989 hasConcept C70721500 @default.
- W2008205989 hasConcept C75268714 @default.
- W2008205989 hasConcept C7602840 @default.
- W2008205989 hasConcept C78458016 @default.
- W2008205989 hasConcept C81917197 @default.
- W2008205989 hasConcept C86803240 @default.
- W2008205989 hasConcept C90132467 @default.
- W2008205989 hasConcept C92938381 @default.
- W2008205989 hasConceptScore W2008205989C104317684 @default.
- W2008205989 hasConceptScore W2008205989C105795698 @default.
- W2008205989 hasConceptScore W2008205989C10853874 @default.
- W2008205989 hasConceptScore W2008205989C153957851 @default.
- W2008205989 hasConceptScore W2008205989C154945302 @default.
- W2008205989 hasConceptScore W2008205989C184898388 @default.
- W2008205989 hasConceptScore W2008205989C193252679 @default.
- W2008205989 hasConceptScore W2008205989C33923547 @default.
- W2008205989 hasConceptScore W2008205989C41008148 @default.
- W2008205989 hasConceptScore W2008205989C515207424 @default.
- W2008205989 hasConceptScore W2008205989C54355233 @default.
- W2008205989 hasConceptScore W2008205989C67705224 @default.
- W2008205989 hasConceptScore W2008205989C70721500 @default.
- W2008205989 hasConceptScore W2008205989C75268714 @default.
- W2008205989 hasConceptScore W2008205989C7602840 @default.
- W2008205989 hasConceptScore W2008205989C78458016 @default.
- W2008205989 hasConceptScore W2008205989C81917197 @default.
- W2008205989 hasConceptScore W2008205989C86803240 @default.
- W2008205989 hasConceptScore W2008205989C90132467 @default.
- W2008205989 hasConceptScore W2008205989C92938381 @default.
- W2008205989 hasIssue "5" @default.
- W2008205989 hasLocation W20082059891 @default.
- W2008205989 hasLocation W20082059892 @default.
- W2008205989 hasOpenAccess W2008205989 @default.
- W2008205989 hasPrimaryLocation W20082059891 @default.
- W2008205989 hasRelatedWork W12279734 @default.
- W2008205989 hasRelatedWork W1624378650 @default.
- W2008205989 hasRelatedWork W1642641254 @default.
- W2008205989 hasRelatedWork W2017754509 @default.
- W2008205989 hasRelatedWork W2058766820 @default.
- W2008205989 hasRelatedWork W2074675159 @default.
- W2008205989 hasRelatedWork W2106136091 @default.
- W2008205989 hasRelatedWork W2144347789 @default.
- W2008205989 hasRelatedWork W2159892619 @default.
- W2008205989 hasRelatedWork W2792658054 @default.
- W2008205989 hasVolume "24" @default.
- W2008205989 isParatext "false" @default.
- W2008205989 isRetracted "false" @default.
- W2008205989 magId "2008205989" @default.
- W2008205989 workType "article" @default.