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• W2008207297 abstract "To Degrade or Not to Degrade Regulating the turnover of proteins within the cell is of fundamental importance to almost every physiological process. Hwang et al. (p. 973 , published online 28 January; see the Perspective by Mogk and Bukau ) now find that acetylated N-terminal methionine (Met) is a degradation signal. This degron is recognized by Saccharomyces cerevisiae Doa10, a transmembrane E3 ubiquitin ligase that resides in the endoplasmic reticulum and inner nuclear membrane. The removal of N-terminal Met by Met-aminopeptidases generates N-terminal residues that are often N-terminally acetylated. Doa10 selectively binds to the resulting N-degrons, which may represent the most prevalent class of cellular protein degradation signals." @default.
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• W2008207297 date "2010-02-19" @default.
• W2008207297 modified "2023-10-18" @default.
• W2008207297 title "N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals" @default.
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• W2008207297 doi "https://doi.org/10.1126/science.1183147" @default.
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