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• W2008209529 startingPage "270" @default.
• W2008209529 abstract "Protective immunity to Mycobacterium tuberculosis is poorly understood, but mounting evidence, at least in animal models, implicates major histocompatibility complex class I-restricted CD8+ T cells as an essential component. By using a highly sensitive assay for single cell interferon gamma release, we screened an array of M. tuberculosis antigen-derived peptides congruent with HLA class I allele-specific motifs. We identified CD8+ T cells specific for epitopes in the early secretory antigenic target 6 during active tuberculosis, after clinical recovery and in healthy contacts. Unrestimulated cells exhibited peptide-specific interferon gamma secretion, whereas lines or clones recognized endogenously processed antigen and showed cytolytic activity. These results provide direct evidence for the involvement of CD8+ cytotoxic T lymphocytes in host defense against M. tuberculosis in humans and support current attempts to generate protective cytotoxic T lymphocyte responses against M. tuberculosis by vaccination." @default.
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• W2008209529 date "1998-01-06" @default.
• W2008209529 modified "2023-09-27" @default.
• W2008209529 title "Human cytolytic and interferon γ-secreting CD8⁺T lymphocytes specific for<i>Mycobacterium tuberculosis</i>" @default.
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• W2008209529 doi "https://doi.org/10.1073/pnas.95.1.270" @default.
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