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• W2008221351 abstract "We examined the effects of the immunosuppressant tacrolimus (FK506) on the discrimination learning impairment induced by chronic cerebral hypoperfusion in rats. Chronic cerebral hypoperfusion was prepared by permanent ligation of bilateral common carotid arteries for male Wistar rats aged 9 weeks. FK506 (0.05 mg/kg, s.c.) recovered the learning impairment and also prevented the rarefaction of white matter and striatal neuronal cell damage. Our findings suggest that FK506 ameliorates the learning impairment mainly due to preventing neuropathological alterations." @default.
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• W2008221351 date "2001-07-01" @default.
• W2008221351 modified "2023-09-25" @default.
• W2008221351 title "FK506 ameliorates the discrimination learning impairment due to preventing the rarefaction of white matter induced by chronic cerebral hypoperfusion in rats" @default.
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• W2008221351 doi "https://doi.org/10.1016/s0006-8993(01)02537-9" @default.
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