FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008222235> ?p ?o ?g. }

• W2008222235 endingPage "210" @default.
• W2008222235 startingPage "203" @default.
• W2008222235 abstract "The lack of transplant vascularization forecloses the generation and clinical implementation of bioartificial tissues. We developed techniques to generate a bioartificial human tissue with an innate vascularization. The tissue was implanted clinically as proof of concept to evaluate vascular network thrombogenicity and tissue viability after transplantation.A porcine small bowl segment was decellularized in a two-step procedure, preserving its vascular structures. The extracellular matrix was characterized quantitatively for DNA residues and protein composition. The vascular remainings were reseeded with human endothelial cells in a dynamic tissue culture. The engineered tissue was characterized by (1) histology, (2) immune-histology, (3) life-dead assay, and (4) metabolic activity. To evaluate the tissue capabilities, it was implanted clinically and recovered after 1 week.Tissue preparation with sodium desoxycholate monohydrate solution resulted in an incomplete decellularization. Cell residues were removed by additional tissue incubation with DNAse. The human endothelial cells formed a viable endothelium inside the primarily porcine extracellular matrix, expressing CD31, Flk-1, and vascular endothelium-cadherin. The metabolic activity of the bioartificial tissue increased continuously over time in vitro. Clinical tissue transplantation confirmed vessel patency and tissue viability for 1 week.The feasibility to bioengineer a human tissue with an innate vascularization has been shown in vitro and the clinical setting. These results may open the door for the clinical application of various sophisticated bioartificial tissue substitutes and organ replacements." @default.
• W2008222235 created "2016-06-24" @default.
• W2008222235 creator A5000174768 @default.
• W2008222235 creator A5005043843 @default.
• W2008222235 creator A5028922669 @default.
• W2008222235 creator A5064000953 @default.
• W2008222235 creator A5064770442 @default.
• W2008222235 creator A5064984109 @default.
• W2008222235 creator A5074560855 @default.
• W2008222235 creator A5076855401 @default.
• W2008222235 creator A5087868911 @default.
• W2008222235 date "2009-07-27" @default.
• W2008222235 modified "2023-10-06" @default.
• W2008222235 title "Generation and Transplantation of an Autologous Vascularized Bioartificial Human Tissue" @default.
• W2008222235 cites W1591982458 @default.
• W2008222235 cites W1963848409 @default.
• W2008222235 cites W1990793260 @default.
• W2008222235 cites W1992426307 @default.
• W2008222235 cites W1994622047 @default.
• W2008222235 cites W1995063875 @default.
• W2008222235 cites W1995474672 @default.
• W2008222235 cites W2008320028 @default.
• W2008222235 cites W2008565536 @default.
• W2008222235 cites W2013411867 @default.
• W2008222235 cites W2017638744 @default.
• W2008222235 cites W2039359804 @default.
• W2008222235 cites W2048366073 @default.
• W2008222235 cites W2050072456 @default.
• W2008222235 cites W2052914625 @default.
• W2008222235 cites W2054526986 @default.
• W2008222235 cites W2059593645 @default.
• W2008222235 cites W2060279594 @default.
• W2008222235 cites W2070789174 @default.
• W2008222235 cites W2074890081 @default.
• W2008222235 cites W2090303367 @default.
• W2008222235 cites W2103722820 @default.
• W2008222235 cites W2120791646 @default.
• W2008222235 cites W2127099066 @default.
• W2008222235 cites W2128488169 @default.
• W2008222235 cites W2143654986 @default.
• W2008222235 cites W2146780202 @default.
• W2008222235 cites W2338831678 @default.
• W2008222235 doi "https://doi.org/10.1097/tp.0b013e3181ac15e1" @default.
• W2008222235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19623015" @default.
• W2008222235 hasPublicationYear "2009" @default.
• W2008222235 type Work @default.
• W2008222235 sameAs 2008222235 @default.
• W2008222235 citedByCount "105" @default.
• W2008222235 countsByYear W20082222352012 @default.
• W2008222235 countsByYear W20082222352013 @default.
• W2008222235 countsByYear W20082222352014 @default.
• W2008222235 countsByYear W20082222352015 @default.
• W2008222235 countsByYear W20082222352016 @default.
• W2008222235 countsByYear W20082222352017 @default.
• W2008222235 countsByYear W20082222352018 @default.
• W2008222235 countsByYear W20082222352019 @default.
• W2008222235 countsByYear W20082222352020 @default.
• W2008222235 countsByYear W20082222352021 @default.
• W2008222235 countsByYear W20082222352022 @default.
• W2008222235 countsByYear W20082222352023 @default.
• W2008222235 crossrefType "journal-article" @default.
• W2008222235 hasAuthorship W2008222235A5000174768 @default.
• W2008222235 hasAuthorship W2008222235A5005043843 @default.
• W2008222235 hasAuthorship W2008222235A5028922669 @default.
• W2008222235 hasAuthorship W2008222235A5064000953 @default.
• W2008222235 hasAuthorship W2008222235A5064770442 @default.
• W2008222235 hasAuthorship W2008222235A5064984109 @default.
• W2008222235 hasAuthorship W2008222235A5074560855 @default.
• W2008222235 hasAuthorship W2008222235A5076855401 @default.
• W2008222235 hasAuthorship W2008222235A5087868911 @default.
• W2008222235 hasConcept C126322002 @default.
• W2008222235 hasConcept C136229726 @default.
• W2008222235 hasConcept C141071460 @default.
• W2008222235 hasConcept C142724271 @default.
• W2008222235 hasConcept C166397571 @default.
• W2008222235 hasConcept C189165786 @default.
• W2008222235 hasConcept C190672674 @default.
• W2008222235 hasConcept C202751555 @default.
• W2008222235 hasConcept C203014093 @default.
• W2008222235 hasConcept C204232928 @default.
• W2008222235 hasConcept C2776649359 @default.
• W2008222235 hasConcept C2776992346 @default.
• W2008222235 hasConcept C2778939058 @default.
• W2008222235 hasConcept C2911091166 @default.
• W2008222235 hasConcept C49892992 @default.
• W2008222235 hasConcept C55493867 @default.
• W2008222235 hasConcept C59822182 @default.
• W2008222235 hasConcept C71924100 @default.
• W2008222235 hasConcept C86803240 @default.
• W2008222235 hasConcept C89560881 @default.
• W2008222235 hasConcept C90703135 @default.
• W2008222235 hasConcept C95444343 @default.
• W2008222235 hasConceptScore W2008222235C126322002 @default.
• W2008222235 hasConceptScore W2008222235C136229726 @default.
• W2008222235 hasConceptScore W2008222235C141071460 @default.
• W2008222235 hasConceptScore W2008222235C142724271 @default.
• W2008222235 hasConceptScore W2008222235C166397571 @default.
• W2008222235 hasConceptScore W2008222235C189165786 @default.

• next