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- W2008223493 endingPage "1047" @default.
- W2008223493 startingPage "1033" @default.
- W2008223493 abstract "Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration.The authors review the development of peptide inhibitors with potential for cancer therapy. Peptides that inhibit signal transduction cascades are discussed.The authors searched Medline for articles concerning the development of therapeutic peptides and their delivery.Given our current knowledge of protein sequences, structures and interaction interfaces, therapeutic peptides that inhibit interactions of interest are easily designed. These peptides are advantageous because they are highly specific for the interaction of interest, and they are much more easily developed than small molecule inhibitors of the same interactions. The main hurdle to application of peptides for cancer therapy is their poor pharmacokinetic and biodistribution parameters. Therefore, successful development of peptide delivery vectors could potentially make possible the use of this new and very promising class of anticancer agents." @default.
- W2008223493 created "2016-06-24" @default.
- W2008223493 creator A5034262384 @default.
- W2008223493 creator A5073630613 @default.
- W2008223493 date "2009-07-29" @default.
- W2008223493 modified "2023-10-18" @default.
- W2008223493 title "Therapeutic peptides for cancer therapy. Part I – peptide inhibitors of signal transduction cascades" @default.
- W2008223493 cites W123581731 @default.
- W2008223493 cites W1505502740 @default.
- W2008223493 cites W1550069159 @default.
- W2008223493 cites W1584683177 @default.
- W2008223493 cites W160450455 @default.
- W2008223493 cites W1635320150 @default.
- W2008223493 cites W1869180711 @default.
- W2008223493 cites W195109764 @default.
- W2008223493 cites W1965583590 @default.
- W2008223493 cites W1966882402 @default.
- W2008223493 cites W1967822571 @default.
- W2008223493 cites W1969999276 @default.
- W2008223493 cites W1972095267 @default.
- W2008223493 cites W1973588973 @default.
- W2008223493 cites W1975664568 @default.
- W2008223493 cites W1976874039 @default.
- W2008223493 cites W1978120999 @default.
- W2008223493 cites W1980902026 @default.
- W2008223493 cites W1981876883 @default.
- W2008223493 cites W1985164165 @default.
- W2008223493 cites W1988156929 @default.
- W2008223493 cites W1988681041 @default.
- W2008223493 cites W1989493412 @default.
- W2008223493 cites W1989557252 @default.
- W2008223493 cites W1990323031 @default.
- W2008223493 cites W1990437207 @default.
- W2008223493 cites W1994271543 @default.
- W2008223493 cites W1994510302 @default.
- W2008223493 cites W1997113487 @default.
- W2008223493 cites W1998033848 @default.
- W2008223493 cites W2002292653 @default.
- W2008223493 cites W2004215940 @default.
- W2008223493 cites W2004706142 @default.
- W2008223493 cites W2006706080 @default.
- W2008223493 cites W2010370535 @default.
- W2008223493 cites W2010503810 @default.
- W2008223493 cites W2013563062 @default.
- W2008223493 cites W2015278662 @default.
- W2008223493 cites W2016488018 @default.
- W2008223493 cites W2018056391 @default.
- W2008223493 cites W2018554367 @default.
- W2008223493 cites W2020488804 @default.
- W2008223493 cites W2020581880 @default.
- W2008223493 cites W2021447146 @default.
- W2008223493 cites W2022840517 @default.
- W2008223493 cites W2023931761 @default.
- W2008223493 cites W2026808860 @default.
- W2008223493 cites W2029346749 @default.
- W2008223493 cites W2029692923 @default.
- W2008223493 cites W2035262124 @default.
- W2008223493 cites W2036693197 @default.
- W2008223493 cites W2041568308 @default.
- W2008223493 cites W2042143995 @default.
- W2008223493 cites W2043860148 @default.
- W2008223493 cites W2044164984 @default.
- W2008223493 cites W2047311244 @default.
- W2008223493 cites W2049662137 @default.
- W2008223493 cites W2052677994 @default.
- W2008223493 cites W2059995799 @default.
- W2008223493 cites W2061209225 @default.
- W2008223493 cites W2063303233 @default.
- W2008223493 cites W2063553906 @default.
- W2008223493 cites W2064308761 @default.
- W2008223493 cites W2067900518 @default.
- W2008223493 cites W2070023258 @default.
- W2008223493 cites W2070461265 @default.
- W2008223493 cites W2072755638 @default.
- W2008223493 cites W2080657810 @default.
- W2008223493 cites W2080910520 @default.
- W2008223493 cites W2084659355 @default.
- W2008223493 cites W2088089215 @default.
- W2008223493 cites W2088328768 @default.
- W2008223493 cites W2089281483 @default.
- W2008223493 cites W2090888546 @default.
- W2008223493 cites W2094375186 @default.
- W2008223493 cites W2094863064 @default.
- W2008223493 cites W2094948453 @default.
- W2008223493 cites W2095152292 @default.
- W2008223493 cites W2096462919 @default.
- W2008223493 cites W2096755059 @default.
- W2008223493 cites W2098806204 @default.
- W2008223493 cites W2098875890 @default.
- W2008223493 cites W2102230863 @default.
- W2008223493 cites W2119044641 @default.
- W2008223493 cites W2119559512 @default.
- W2008223493 cites W2119790258 @default.
- W2008223493 cites W2125558097 @default.
- W2008223493 cites W2128308066 @default.
- W2008223493 cites W2137210959 @default.
- W2008223493 cites W2139874251 @default.
- W2008223493 cites W2141695685 @default.