Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008224290> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2008224290 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCObjective: Ovarian cancer may arise from a subpopulation of CD133+ 44+ cells, which are self-renewing tumor-initiating cells.Materials and Methods: We investigated the tumorigenicity of the cell line A2780 which is CD133high44low, the cell line A2780 with siRNA against CD133 (CD133low44low), and human ovarian cancer cells from ascites, from primary ovarian cancer, and from metastatic ovarian cancer (CD133 high/CD44high) harvested from patients at the time of surgical cytoreduction in ultra low attachment plates in serum free medium. Spheroids from each of these sources were used to test their tumorigenicity in SCID mice.Results: Cells from A2780 cell line (CD133 high/CD44low) formed tumors in SCID mice in 2 months but silencing CD133 with siRNA CD133 (CD133 low/CD44low) inhibited tumorigenicity in SCID mice and retarded but did not prevent spheroid formation. Spheroid cultures of ascites, primary ovary, and metastasis (CD133 high/CD44high) are capable of inducing primary ovarian tumors and metastatic tumors in SCID mice in 2 months compared to 4-6 months in sorted, non-spheroid cells.Conclusions: The data suggest that CD133 expression is necessary for tumorigenesis in the A2780 cell line but not for spheroid formation. Our data also suggests that spheroids which are CD133 high/CD44high from human tumor recapitulate ovarian cancer in women. These novel in vivo and vitro models may offer useful tools to develop therapies targeted to ovarian cancer.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4312." @default.
- W2008224290 created "2016-06-24" @default.
- W2008224290 creator A5024805999 @default.
- W2008224290 creator A5029494360 @default.
- W2008224290 creator A5038892604 @default.
- W2008224290 creator A5042481304 @default.
- W2008224290 creator A5068376674 @default.
- W2008224290 date "2010-04-15" @default.
- W2008224290 modified "2023-09-25" @default.
- W2008224290 title "Abstract 4312: Identification of putative stem cell markers of CD133 and CD44 in human ovarian cancer specimens and ovarian cancer cell lines" @default.
- W2008224290 doi "https://doi.org/10.1158/1538-7445.am10-4312" @default.
- W2008224290 hasPublicationYear "2010" @default.
- W2008224290 type Work @default.
- W2008224290 sameAs 2008224290 @default.
- W2008224290 citedByCount "0" @default.
- W2008224290 crossrefType "proceedings-article" @default.
- W2008224290 hasAuthorship W2008224290A5024805999 @default.
- W2008224290 hasAuthorship W2008224290A5029494360 @default.
- W2008224290 hasAuthorship W2008224290A5038892604 @default.
- W2008224290 hasAuthorship W2008224290A5042481304 @default.
- W2008224290 hasAuthorship W2008224290A5068376674 @default.
- W2008224290 hasConcept C121608353 @default.
- W2008224290 hasConcept C126322002 @default.
- W2008224290 hasConcept C136302470 @default.
- W2008224290 hasConcept C142724271 @default.
- W2008224290 hasConcept C1491633281 @default.
- W2008224290 hasConcept C2779013556 @default.
- W2008224290 hasConcept C2780427987 @default.
- W2008224290 hasConcept C2780932548 @default.
- W2008224290 hasConcept C28328180 @default.
- W2008224290 hasConcept C502942594 @default.
- W2008224290 hasConcept C54355233 @default.
- W2008224290 hasConcept C55427017 @default.
- W2008224290 hasConcept C555283112 @default.
- W2008224290 hasConcept C71924100 @default.
- W2008224290 hasConcept C81885089 @default.
- W2008224290 hasConcept C86803240 @default.
- W2008224290 hasConcept C95444343 @default.
- W2008224290 hasConceptScore W2008224290C121608353 @default.
- W2008224290 hasConceptScore W2008224290C126322002 @default.
- W2008224290 hasConceptScore W2008224290C136302470 @default.
- W2008224290 hasConceptScore W2008224290C142724271 @default.
- W2008224290 hasConceptScore W2008224290C1491633281 @default.
- W2008224290 hasConceptScore W2008224290C2779013556 @default.
- W2008224290 hasConceptScore W2008224290C2780427987 @default.
- W2008224290 hasConceptScore W2008224290C2780932548 @default.
- W2008224290 hasConceptScore W2008224290C28328180 @default.
- W2008224290 hasConceptScore W2008224290C502942594 @default.
- W2008224290 hasConceptScore W2008224290C54355233 @default.
- W2008224290 hasConceptScore W2008224290C55427017 @default.
- W2008224290 hasConceptScore W2008224290C555283112 @default.
- W2008224290 hasConceptScore W2008224290C71924100 @default.
- W2008224290 hasConceptScore W2008224290C81885089 @default.
- W2008224290 hasConceptScore W2008224290C86803240 @default.
- W2008224290 hasConceptScore W2008224290C95444343 @default.
- W2008224290 hasLocation W20082242901 @default.
- W2008224290 hasOpenAccess W2008224290 @default.
- W2008224290 hasPrimaryLocation W20082242901 @default.
- W2008224290 hasRelatedWork W1483504868 @default.
- W2008224290 hasRelatedWork W1590528748 @default.
- W2008224290 hasRelatedWork W1957032643 @default.
- W2008224290 hasRelatedWork W1964164184 @default.
- W2008224290 hasRelatedWork W2017489298 @default.
- W2008224290 hasRelatedWork W2018047723 @default.
- W2008224290 hasRelatedWork W2025317307 @default.
- W2008224290 hasRelatedWork W2032036028 @default.
- W2008224290 hasRelatedWork W2038225686 @default.
- W2008224290 hasRelatedWork W2062697989 @default.
- W2008224290 hasRelatedWork W2078828659 @default.
- W2008224290 hasRelatedWork W2139151018 @default.
- W2008224290 hasRelatedWork W2546778197 @default.
- W2008224290 hasRelatedWork W2930923612 @default.
- W2008224290 hasRelatedWork W2972179065 @default.
- W2008224290 hasRelatedWork W3013978542 @default.
- W2008224290 hasRelatedWork W3034014989 @default.
- W2008224290 hasRelatedWork W3082919449 @default.
- W2008224290 hasRelatedWork W3111466268 @default.
- W2008224290 hasRelatedWork W2789167353 @default.
- W2008224290 isParatext "false" @default.
- W2008224290 isRetracted "false" @default.
- W2008224290 magId "2008224290" @default.
- W2008224290 workType "article" @default.