FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008231808> ?p ?o ?g. }

• W2008231808 abstract "Partly because of functional genomics, there has been a major paradigm shift from solely thinking of skeletal muscle as contractile machinery to an understanding that it can have roles in paracrine and endocrine functions. Physical inactivity is an established risk factor for some blood clotting disorders. The effects of inactivity during sitting are most alarming when a person develops the enigmatic condition in the legs called deep venous thrombosis (DVT) or coach syndrome, caused in part by muscular inactivity. The goal of this study was to determine if skeletal muscle expresses genes with roles in hemostasis and if their expression level was responsive to muscular inactivity such as occurs in prolonged sitting.Microarray analyses were performed on skeletal muscle samples from rats and humans to identify genes associated with hemostatic function that were significantly expressed above background based on multiple probe sets with perfect and mismatch sequences. Furthermore, we determined if any of these genes were responsive to models of physical inactivity. Multiple criteria were used to determine differential expression including significant expression above background, fold change, and non-parametric statistical tests.These studies demonstrate skeletal muscle tissue expresses at least 17 genes involved in hemostasis. These include the fibrinolytic factors tetranectin, annexin A2, and tPA; the anti-coagulant factors TFPI, protein C receptor, PAF acetylhydrolase; coagulation factors, and genes necessary for the posttranslational modification of these coagulation factors such as vitamin K epoxide reductase. Of special interest, lipid phosphate phosphatase-1 (LPP1/PAP2A), a key gene for degrading prothrombotic and proinflammatory lysophospholipids, was suppressed locally in muscle tissue within hours after sitting in humans; this was also observed after acute and chronic physical inactivity conditions in rats, and exercise was relatively ineffective at counteracting this effect in both species.These findings suggest that skeletal muscle may play an important role in hemostasis and that muscular inactivity may contribute to hemostatic disorders not only because of the slowing of blood flow per se, but also potentially because of the contribution from genes expressed locally in muscles, such as LPP1." @default.
• W2008231808 created "2016-06-24" @default.
• W2008231808 creator A5054513283 @default.
• W2008231808 creator A5058412939 @default.
• W2008231808 date "2012-10-12" @default.
• W2008231808 modified "2023-09-24" @default.
• W2008231808 title "Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2A) suppressed during prolonged physical inactivity (sitting)" @default.
• W2008231808 cites W112886495 @default.
• W2008231808 cites W1965966865 @default.
• W2008231808 cites W2001233469 @default.
• W2008231808 cites W2006441443 @default.
• W2008231808 cites W2008914676 @default.
• W2008231808 cites W2014473242 @default.
• W2008231808 cites W2018794455 @default.
• W2008231808 cites W2021389931 @default.
• W2008231808 cites W2032122936 @default.
• W2008231808 cites W2043047817 @default.
• W2008231808 cites W2058152210 @default.
• W2008231808 cites W2063505817 @default.
• W2008231808 cites W2065231049 @default.
• W2008231808 cites W2071792310 @default.
• W2008231808 cites W2072861616 @default.
• W2008231808 cites W2076141362 @default.
• W2008231808 cites W2077581495 @default.
• W2008231808 cites W2086475013 @default.
• W2008231808 cites W2089053666 @default.
• W2008231808 cites W2106514058 @default.
• W2008231808 cites W2124496590 @default.
• W2008231808 cites W2127100580 @default.
• W2008231808 cites W2132928522 @default.
• W2008231808 cites W2141583613 @default.
• W2008231808 cites W2144269735 @default.
• W2008231808 cites W2145025818 @default.
• W2008231808 cites W2160320069 @default.
• W2008231808 cites W2162523749 @default.
• W2008231808 cites W2403760872 @default.
• W2008231808 cites W4243230640 @default.
• W2008231808 doi "https://doi.org/10.1186/1476-511x-11-137" @default.
• W2008231808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3539950" @default.
• W2008231808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23061662" @default.
• W2008231808 hasPublicationYear "2012" @default.
• W2008231808 type Work @default.
• W2008231808 sameAs 2008231808 @default.
• W2008231808 citedByCount "24" @default.
• W2008231808 countsByYear W20082318082013 @default.
• W2008231808 countsByYear W20082318082014 @default.
• W2008231808 countsByYear W20082318082016 @default.
• W2008231808 countsByYear W20082318082017 @default.
• W2008231808 countsByYear W20082318082018 @default.
• W2008231808 countsByYear W20082318082019 @default.
• W2008231808 countsByYear W20082318082021 @default.
• W2008231808 countsByYear W20082318082022 @default.
• W2008231808 countsByYear W20082318082023 @default.
• W2008231808 crossrefType "journal-article" @default.
• W2008231808 hasAuthorship W2008231808A5054513283 @default.
• W2008231808 hasAuthorship W2008231808A5058412939 @default.
• W2008231808 hasBestOaLocation W20082318081 @default.
• W2008231808 hasConcept C126322002 @default.
• W2008231808 hasConcept C134018914 @default.
• W2008231808 hasConcept C2778589496 @default.
• W2008231808 hasConcept C2779959927 @default.
• W2008231808 hasConcept C71924100 @default.
• W2008231808 hasConcept C86803240 @default.
• W2008231808 hasConceptScore W2008231808C126322002 @default.
• W2008231808 hasConceptScore W2008231808C134018914 @default.
• W2008231808 hasConceptScore W2008231808C2778589496 @default.
• W2008231808 hasConceptScore W2008231808C2779959927 @default.
• W2008231808 hasConceptScore W2008231808C71924100 @default.
• W2008231808 hasConceptScore W2008231808C86803240 @default.
• W2008231808 hasIssue "1" @default.
• W2008231808 hasLocation W20082318081 @default.
• W2008231808 hasLocation W20082318082 @default.
• W2008231808 hasLocation W20082318083 @default.
• W2008231808 hasLocation W20082318084 @default.
• W2008231808 hasOpenAccess W2008231808 @default.
• W2008231808 hasPrimaryLocation W20082318081 @default.
• W2008231808 hasRelatedWork W1974568996 @default.
• W2008231808 hasRelatedWork W2016840789 @default.
• W2008231808 hasRelatedWork W2048328229 @default.
• W2008231808 hasRelatedWork W2081376013 @default.
• W2008231808 hasRelatedWork W2144576666 @default.
• W2008231808 hasRelatedWork W2309978229 @default.
• W2008231808 hasRelatedWork W2463478234 @default.
• W2008231808 hasRelatedWork W3032853368 @default.
• W2008231808 hasRelatedWork W4383602876 @default.
• W2008231808 hasRelatedWork W1986686866 @default.
• W2008231808 hasVolume "11" @default.
• W2008231808 isParatext "false" @default.
• W2008231808 isRetracted "false" @default.
• W2008231808 magId "2008231808" @default.
• W2008231808 workType "article" @default.