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- W2008235320 abstract "Objective. To correlate the spin-spin relaxation time (T2) of brain tissue in neuropsychiatric systemic lupus erythematosus (NPSLE) with the patient's clinical condition. Methods. T2 values were determined in 54 SLE patients and 45 non-SLE controls at 1.5 Tesla, using intensity from multi-echo magnetic resonance (MR) images fitted to an exponential decay curve with rateconstant T2. Results. The T2 of white matter was increased in SLE patients compared with controls (P = 0.01) and was increased in those patients who had previously experienced major NPSLE. Patients with acute diffuse neurologic manifestations (seizures, psychosis, coma) demonstrated a longer T2 of the gray matter (mean ± SD 92.75 ± 6.35 ms, n = 10) than did other SLE patients (mean ± SD 79.61 ± 5.04 ms, n = 44) (P = 0.02 by t-test), which suggests acute cerebral edema. The mean T2 values of reversible and nonreversible focal lesions were significantly different (P < 0.02), indicating different microenvironments and micropathology. Conclusion. Quantitative T2 measurement extends the utility and sensitivity of conventional MR imaging for evaluating NPSLE." @default.
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- W2008235320 date "1995-06-01" @default.
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- W2008235320 title "Spin-spin relaxation of brain tissues in systemic lupus erythematosus" @default.
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- W2008235320 doi "https://doi.org/10.1002/art.1780380615" @default.
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