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• W2008235504 abstract "The physicochemical properties, p K a , Log P and solubility of compound alpha, (5‐chloro‐2‐(methylthio)‐6‐(1‐naphthyloxy)‐1 H ‐benzimidazole), a new fasciolicide agent, were characterized using conventional methods. Also, its pharmacokinetics was evaluated in sheep and cattle. In both species an oral dose of 12 mg/kg was administered. Blood samples were collected during 144 h and analyzed by using an HPLC assay. Results showed that compound alpha is a weak base with a p K a value of 2.87 and log P of 1.44. The solubility was very low in aqueous solvents. Pharmacokinetic studies showed that in both species compound alpha could not be detected at any sampling time. The mean half‐life ( t ½ ) values of alpha sulphoxide in sheep and cattle were 19.86 and 29.87 h, while the half‐life values of alpha sulphone were 19.43 and 46.32 h respectively. C max values of alpha sulphoxide did not differ between species while alpha sulphone values were higher in cattle. Plasma protein binding of alpha sulphoxide was between 82% and 86%. These results, combined with the previous efficacy studies, suggest that compound alpha could be a promising fasciolicide agent." @default.
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• W2008235504 date "2009-03-06" @default.
• W2008235504 modified "2023-10-18" @default.
• W2008235504 title "Pharmacokinetic behavior in sheep and cattle of 5-chloro-2-(methylthio)-6-(1-naphthyloxy)-1<i>H</i>-benzimidazole, a new fasciolicide agent" @default.
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• W2008235504 doi "https://doi.org/10.1111/j.1365-2885.2008.01014.x" @default.
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