FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008235942> ?p ?o ?g. }

• W2008235942 endingPage "1029" @default.
• W2008235942 startingPage "1024" @default.
• W2008235942 abstract "The role of platelet activating factor (PAF) in asthma remains controversial. The priming effect of PAF on leukotriene B4 (LTB4) release, 5-lipoxygenase activity, and intracellular calcium levels in asthmatic neutrophils was examined.LTB4 and other lipoxygenase metabolites in neutrophils obtained from 17 asthmatic patients and 15 control subjects were measured by reverse phase-high performance liquid chromatography (RP-HPLC). Intracellular calcium levels were monitored using the fluorescent probe fura-2.The mean (SD) basal LTB4, release from neutrophils was not significantly different between the two groups (0.05 (0.01) vs 0.03 (0.02) ng/10(6) cells); however, when stimulated with calcium ionophore A23187 (2.5 microM), neutrophils from asthma patients released more LTB4 than cells from control subjects (15.7 (1.2) vs 9.9 (1.6) ng/10(6) cells). Although PAF alone did not alter LTB4 release, it enhanced the response to subsequent A23187 stimulation. This effect was observed following treatment for five minutes with PAF at concentrations > 1.0 microM. The maximal effect was seen with 5.0 microM PAF + 2.5 microM A23187 (62.7 (2.2) vs 18.6 (2.3) ng/10(6) cells). Pretreatment with PAF also increased 5-lipoxygenase activity and intracellular calcium levels in neutrophils from asthmatic patients to a greater extent than in those from non-asthmatic patients.These findings indicate that, in neutrophils from asthmatic patients, PAF enhances LTB4 release and increases 5-lipoxygenase activity and intracellular calcium to a greater extent than in neutrophils from non-asthmatic patients." @default.
• W2008235942 created "2016-06-24" @default.
• W2008235942 creator A5038928126 @default.
• W2008235942 creator A5072273810 @default.
• W2008235942 creator A5073194290 @default.
• W2008235942 date "1997-12-01" @default.
• W2008235942 modified "2023-10-03" @default.
• W2008235942 title "Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor" @default.
• W2008235942 cites W1509307264 @default.
• W2008235942 cites W1521454905 @default.
• W2008235942 cites W1776763082 @default.
• W2008235942 cites W1902325315 @default.
• W2008235942 cites W1981818027 @default.
• W2008235942 cites W1985405157 @default.
• W2008235942 cites W1987719390 @default.
• W2008235942 cites W1996979958 @default.
• W2008235942 cites W2004351423 @default.
• W2008235942 cites W2011921884 @default.
• W2008235942 cites W2021336881 @default.
• W2008235942 cites W2026402589 @default.
• W2008235942 cites W2030470893 @default.
• W2008235942 cites W2031908250 @default.
• W2008235942 cites W2037083082 @default.
• W2008235942 cites W2042694362 @default.
• W2008235942 cites W2043591304 @default.
• W2008235942 cites W2049007654 @default.
• W2008235942 cites W2053551700 @default.
• W2008235942 cites W2055114025 @default.
• W2008235942 cites W2071092858 @default.
• W2008235942 cites W2084788087 @default.
• W2008235942 cites W2090028387 @default.
• W2008235942 cites W2104250439 @default.
• W2008235942 cites W2120407354 @default.
• W2008235942 cites W2121121770 @default.
• W2008235942 cites W2121721745 @default.
• W2008235942 cites W2122999278 @default.
• W2008235942 cites W2128635872 @default.
• W2008235942 cites W2134674910 @default.
• W2008235942 cites W2153912688 @default.
• W2008235942 cites W2154527395 @default.
• W2008235942 cites W2178942471 @default.
• W2008235942 cites W2344184125 @default.
• W2008235942 cites W4236639597 @default.
• W2008235942 cites W4293247451 @default.
• W2008235942 cites W87082738 @default.
• W2008235942 doi "https://doi.org/10.1136/thx.52.12.1024" @default.
• W2008235942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1758460" @default.
• W2008235942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9516893" @default.
• W2008235942 hasPublicationYear "1997" @default.
• W2008235942 type Work @default.
• W2008235942 sameAs 2008235942 @default.
• W2008235942 citedByCount "29" @default.
• W2008235942 countsByYear W20082359422013 @default.
• W2008235942 countsByYear W20082359422016 @default.
• W2008235942 countsByYear W20082359422017 @default.
• W2008235942 countsByYear W20082359422019 @default.
• W2008235942 countsByYear W20082359422020 @default.
• W2008235942 crossrefType "journal-article" @default.
• W2008235942 hasAuthorship W2008235942A5038928126 @default.
• W2008235942 hasAuthorship W2008235942A5072273810 @default.
• W2008235942 hasAuthorship W2008235942A5073194290 @default.
• W2008235942 hasBestOaLocation W20082359421 @default.
• W2008235942 hasConcept C126322002 @default.
• W2008235942 hasConcept C134018914 @default.
• W2008235942 hasConcept C181080969 @default.
• W2008235942 hasConcept C181199279 @default.
• W2008235942 hasConcept C185592680 @default.
• W2008235942 hasConcept C198677920 @default.
• W2008235942 hasConcept C203014093 @default.
• W2008235942 hasConcept C24998067 @default.
• W2008235942 hasConcept C2776042228 @default.
• W2008235942 hasConcept C2776452501 @default.
• W2008235942 hasConcept C2776685179 @default.
• W2008235942 hasConcept C2776914184 @default.
• W2008235942 hasConcept C2779020240 @default.
• W2008235942 hasConcept C2780857362 @default.
• W2008235942 hasConcept C519063684 @default.
• W2008235942 hasConcept C55493867 @default.
• W2008235942 hasConcept C71924100 @default.
• W2008235942 hasConcept C79879829 @default.
• W2008235942 hasConcept C89560881 @default.
• W2008235942 hasConcept C98274493 @default.
• W2008235942 hasConceptScore W2008235942C126322002 @default.
• W2008235942 hasConceptScore W2008235942C134018914 @default.
• W2008235942 hasConceptScore W2008235942C181080969 @default.
• W2008235942 hasConceptScore W2008235942C181199279 @default.
• W2008235942 hasConceptScore W2008235942C185592680 @default.
• W2008235942 hasConceptScore W2008235942C198677920 @default.
• W2008235942 hasConceptScore W2008235942C203014093 @default.
• W2008235942 hasConceptScore W2008235942C24998067 @default.
• W2008235942 hasConceptScore W2008235942C2776042228 @default.
• W2008235942 hasConceptScore W2008235942C2776452501 @default.
• W2008235942 hasConceptScore W2008235942C2776685179 @default.
• W2008235942 hasConceptScore W2008235942C2776914184 @default.
• W2008235942 hasConceptScore W2008235942C2779020240 @default.
• W2008235942 hasConceptScore W2008235942C2780857362 @default.
• W2008235942 hasConceptScore W2008235942C519063684 @default.
• W2008235942 hasConceptScore W2008235942C55493867 @default.

• next