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• W2008242161 abstract "To investigate the relationship between neuronal death and intracellular calcium homeostasis in brains from patients with Alzheimer's disease (AD), we quantitatively analyzed morphological changes of calbindin-immunoreactive neurons. Neuronal counts were made in the autopsy brains from 6 control and 6 AD patients. Calbindin-immunoreactive neurons were mainly distributed in cortical layer II and were selectively lost in the AD brains. Further, the number of calbindin-immunoreactive neurons showed a negative correlation with age in the control group. These findings strongly suggest that age-related reduction of calbindin-immunoreactive neurons may be exaggerated in AD brains and change in calcium homeostasis may be involved in the pathogenesis of AD." @default.
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• W2008242161 date "1993-12-01" @default.
• W2008242161 modified "2023-09-27" @default.
• W2008242161 title "Selective loss of calbindin D28K-immunoreative neurons in the cortical layer II in brains of Alzheimer's disease: a morphometric study" @default.
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• W2008242161 doi "https://doi.org/10.1016/0304-3940(93)90388-2" @default.
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