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- W2008247941 abstract "Carbohydrate-deficient transferrin (CDT) has emerged as the best new marker for alcohol abuse. Recently plasma immunoglobulin A (IgA) reactivity with acetaldehyde (AcH)-modified proteins, or the modified proteins per se, have been proposed as a markers for high levels of alcohol consumption. In this study, we have compared CDT, IgA reactivity with AcH adducts (IgA ASR), and AcH-modified albumin with conventional markers of high alcohol intake in groups with well-defined drinking histories. The plasma activity of ALT, AST, and γ-glutamyltransferase increased steadily with increasing alcohol consumption. CDT and AcH-modified albumin showed a similar pattern, whereas IgA ASR appeared only to be elevated after a threshold level of consumption had been reached. Neither CDT IgA ASR or AcH-modified albumin correlated strongly with any of the conventional markers or each other. This study shows that CDT, IgA ASR, AcH-modified albumin, and the conventional markers are not related, but suggests that the concurrent use of CDT and IgA ASR may lead to better identification of high alcohol intake." @default.
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- W2008247941 date "1998-12-01" @default.
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- W2008247941 title "Comparison of Carbohydrate-Deficient Transferrin, Immunoglobulin A Antibodies Reactive with Acetaldehyde-Modified Protein and Acetaldehyde-Modified Albumin with Conventional Markers of Alcohol Consumption" @default.
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- W2008247941 doi "https://doi.org/10.1111/j.1530-0277.1998.tb05899.x" @default.
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