FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008248840> ?p ?o ?g. }

• W2008248840 endingPage "e14033" @default.
• W2008248840 startingPage "e14033" @default.
• W2008248840 abstract "Background As a culmination of efforts over the last years, our knowledge of the embryonic origins of the mammalian frontal and parietal cranial bones is unambiguous. Progenitor cells that subsequently give rise to frontal bone are of neural crest origin, while parietal bone progenitors arise from paraxial mesoderm. Given the unique qualities of neural crest cells and the clear delineation of the embryonic origins of the calvarial bones, we sought to determine whether mouse neural crest derived frontal bone differs in biology from mesoderm derived parietal bone. Methods BrdU incorporation, immunoblotting and osteogenic differentiation assays were performed to investigate the proliferative rate and osteogenic potential of embryonic and postnatal osteoblasts derived from mouse frontal and parietal bones. Co-culture experiments and treatment with conditioned medium harvested from both types of osteoblasts were performed to investigate potential interactions between the two different tissue origin osteoblasts. Immunoblotting techniques were used to investigate the endogenous level of FGF-2 and the activation of three major FGF signaling pathways. Knockdown of FGF Receptor 1 (FgfR1) was employed to inactivate the FGF signaling. Results Our results demonstrated that striking differences in cell proliferation and osteogenic differentiation between the frontal and parietal bone can be detected already at embryonic stages. The greater proliferation rate, as well as osteogenic capacity of frontal bone derived osteoblasts, were paralleled by an elevated level of FGF-2 protein synthesis. Moreover, an enhanced activation of FGF-signaling pathways was observed in frontal bone derived osteoblasts. Finally, the greater osteogenic potential of frontal derived osteoblasts was dramatically impaired by knocking down FgfR1. Conclusions Osteoblasts from mouse neural crest derived frontal bone displayed a greater proliferative and osteogenic potential and endogenous enhanced activation of FGF signaling compared to osteoblasts from mesoderm derived parietal bone. FGF signaling plays a key role in determining biological differences between the two types of osteoblasts." @default.
• W2008248840 created "2016-06-24" @default.
• W2008248840 creator A5005728573 @default.
• W2008248840 creator A5040238984 @default.
• W2008248840 creator A5045868108 @default.
• W2008248840 date "2010-11-18" @default.
• W2008248840 modified "2023-10-16" @default.
• W2008248840 title "Activation of FGF Signaling Mediates Proliferative and Osteogenic Differences between Neural Crest Derived Frontal and Mesoderm Parietal Derived Bone" @default.
• W2008248840 cites W1494349315 @default.
• W2008248840 cites W1988127349 @default.
• W2008248840 cites W1997107243 @default.
• W2008248840 cites W2002254327 @default.
• W2008248840 cites W2011155633 @default.
• W2008248840 cites W2011234976 @default.
• W2008248840 cites W2020830179 @default.
• W2008248840 cites W2032441881 @default.
• W2008248840 cites W2033255624 @default.
• W2008248840 cites W2035510188 @default.
• W2008248840 cites W2037499635 @default.
• W2008248840 cites W2038675898 @default.
• W2008248840 cites W2042545863 @default.
• W2008248840 cites W2043471588 @default.
• W2008248840 cites W2045065892 @default.
• W2008248840 cites W2046637649 @default.
• W2008248840 cites W2047939663 @default.
• W2008248840 cites W2051180982 @default.
• W2008248840 cites W2057888154 @default.
• W2008248840 cites W2067872631 @default.
• W2008248840 cites W2075563020 @default.
• W2008248840 cites W2077517942 @default.
• W2008248840 cites W2089016492 @default.
• W2008248840 cites W2093630187 @default.
• W2008248840 cites W2102894828 @default.
• W2008248840 cites W2114239412 @default.
• W2008248840 cites W2115237445 @default.
• W2008248840 cites W2122892477 @default.
• W2008248840 cites W2137256580 @default.
• W2008248840 cites W2140543158 @default.
• W2008248840 cites W2141516235 @default.
• W2008248840 cites W2147114673 @default.
• W2008248840 cites W2147245058 @default.
• W2008248840 cites W2151417014 @default.
• W2008248840 cites W2154330374 @default.
• W2008248840 cites W2393861604 @default.
• W2008248840 doi "https://doi.org/10.1371/journal.pone.0014033" @default.
• W2008248840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2987799" @default.
• W2008248840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21124973" @default.
• W2008248840 hasPublicationYear "2010" @default.
• W2008248840 type Work @default.
• W2008248840 sameAs 2008248840 @default.
• W2008248840 citedByCount "52" @default.
• W2008248840 countsByYear W20082488402012 @default.
• W2008248840 countsByYear W20082488402013 @default.
• W2008248840 countsByYear W20082488402014 @default.
• W2008248840 countsByYear W20082488402015 @default.
• W2008248840 countsByYear W20082488402016 @default.
• W2008248840 countsByYear W20082488402017 @default.
• W2008248840 countsByYear W20082488402018 @default.
• W2008248840 countsByYear W20082488402019 @default.
• W2008248840 countsByYear W20082488402020 @default.
• W2008248840 countsByYear W20082488402021 @default.
• W2008248840 countsByYear W20082488402022 @default.
• W2008248840 countsByYear W20082488402023 @default.
• W2008248840 crossrefType "journal-article" @default.
• W2008248840 hasAuthorship W2008248840A5005728573 @default.
• W2008248840 hasAuthorship W2008248840A5040238984 @default.
• W2008248840 hasAuthorship W2008248840A5045868108 @default.
• W2008248840 hasBestOaLocation W20082488401 @default.
• W2008248840 hasConcept C104317684 @default.
• W2008248840 hasConcept C105702510 @default.
• W2008248840 hasConcept C122428330 @default.
• W2008248840 hasConcept C126322002 @default.
• W2008248840 hasConcept C126749454 @default.
• W2008248840 hasConcept C134018914 @default.
• W2008248840 hasConcept C145103041 @default.
• W2008248840 hasConcept C170493617 @default.
• W2008248840 hasConcept C196843134 @default.
• W2008248840 hasConcept C201750760 @default.
• W2008248840 hasConcept C202751555 @default.
• W2008248840 hasConcept C2777598532 @default.
• W2008248840 hasConcept C2778260815 @default.
• W2008248840 hasConcept C2779300802 @default.
• W2008248840 hasConcept C2780071072 @default.
• W2008248840 hasConcept C2780322005 @default.
• W2008248840 hasConcept C2780915607 @default.
• W2008248840 hasConcept C28328180 @default.
• W2008248840 hasConcept C54355233 @default.
• W2008248840 hasConcept C71924100 @default.
• W2008248840 hasConcept C74373430 @default.
• W2008248840 hasConcept C86803240 @default.
• W2008248840 hasConcept C95444343 @default.
• W2008248840 hasConceptScore W2008248840C104317684 @default.
• W2008248840 hasConceptScore W2008248840C105702510 @default.
• W2008248840 hasConceptScore W2008248840C122428330 @default.
• W2008248840 hasConceptScore W2008248840C126322002 @default.
• W2008248840 hasConceptScore W2008248840C126749454 @default.
• W2008248840 hasConceptScore W2008248840C134018914 @default.
• W2008248840 hasConceptScore W2008248840C145103041 @default.

• next