FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008259394> ?p ?o ?g. }

• W2008259394 endingPage "1041" @default.
• W2008259394 startingPage "1032" @default.
• W2008259394 abstract "Abstract Disruption of circadian machinery appears to be associated with the acceleration of tumor development. To evaluate the function of the circadian clock during neoplastic transformation, the daily profiles of the core clock genes Per1, Per2, Rev‐Erbα and Bmal1 , the clock‐controlled gene Dbp and the clock‐controlled cell cycle genes Wee1 , c‐Myc and p21 were detected by real‐time RT‐PCR in chemically induced primary colorectal tumors, the surrounding normal tissue and in the liver. The circadian rhythmicity of Per1 , Per2 , Rev‐Erbα and Dbp was significantly reduced in tumor compared with healthy colon and the rhythmicity of Bmal1 was completely abolished. Interestingly, the circadian expression of Per1 , Per2 , Rev‐Erbα and Dbp persisted in the colonic tissue surrounding the tumor but the rhythmic expression of Bmal1 was also abolished. Daily profiles of Wee1 , c‐Myc and p21 did not exhibit any rhythmicity either in tumors or in the colon of healthy animals. The absence of diurnal rhythmicity of cell cycle genes was partially associated with ageing, because young healthy mice showed rhythmicity in the core clock genes as well as in the Wee1 and p21 . In the liver of tumor‐bearing mice the clock gene rhythms were temporally shifted. The data suggest that the circadian regulation is distorted in colonic neoplastic tissue and that the gene‐specific disruption may be also observed in the non‐neoplastic tissues. These findings reinforce the role of peripheral circadian clockwork disruption for carcinogenesis and tumor progression." @default.
• W2008259394 created "2016-06-24" @default.
• W2008259394 creator A5001656619 @default.
• W2008259394 creator A5046299969 @default.
• W2008259394 creator A5072073786 @default.
• W2008259394 creator A5074628206 @default.
• W2008259394 creator A5076947309 @default.
• W2008259394 date "2012-08-24" @default.
• W2008259394 modified "2023-10-18" @default.
• W2008259394 title "An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors" @default.
• W2008259394 cites W1491860558 @default.
• W2008259394 cites W1964244253 @default.
• W2008259394 cites W1970988995 @default.
• W2008259394 cites W1974359212 @default.
• W2008259394 cites W1976471753 @default.
• W2008259394 cites W1976540475 @default.
• W2008259394 cites W1980685856 @default.
• W2008259394 cites W1981307611 @default.
• W2008259394 cites W1990821337 @default.
• W2008259394 cites W1991333402 @default.
• W2008259394 cites W1997179110 @default.
• W2008259394 cites W2000811716 @default.
• W2008259394 cites W2001303266 @default.
• W2008259394 cites W2016397316 @default.
• W2008259394 cites W2023224277 @default.
• W2008259394 cites W2033646753 @default.
• W2008259394 cites W2041838266 @default.
• W2008259394 cites W2042980634 @default.
• W2008259394 cites W2050876913 @default.
• W2008259394 cites W2053243600 @default.
• W2008259394 cites W2053406327 @default.
• W2008259394 cites W2054305159 @default.
• W2008259394 cites W2055780432 @default.
• W2008259394 cites W2056505464 @default.
• W2008259394 cites W2070252821 @default.
• W2008259394 cites W2074702672 @default.
• W2008259394 cites W2077038726 @default.
• W2008259394 cites W2080663355 @default.
• W2008259394 cites W2084074983 @default.
• W2008259394 cites W2085845055 @default.
• W2008259394 cites W2095033284 @default.
• W2008259394 cites W2097479597 @default.
• W2008259394 cites W2102914417 @default.
• W2008259394 cites W2128032039 @default.
• W2008259394 cites W2132176657 @default.
• W2008259394 cites W2138757419 @default.
• W2008259394 cites W2139844513 @default.
• W2008259394 cites W2140464373 @default.
• W2008259394 cites W2147322410 @default.
• W2008259394 cites W2150081842 @default.
• W2008259394 cites W2150660191 @default.
• W2008259394 cites W2157481078 @default.
• W2008259394 cites W2160054542 @default.
• W2008259394 cites W2161548459 @default.
• W2008259394 cites W2163183531 @default.
• W2008259394 cites W2163531378 @default.
• W2008259394 cites W2164074733 @default.
• W2008259394 cites W2324947625 @default.
• W2008259394 doi "https://doi.org/10.1002/ijc.27760" @default.
• W2008259394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22865596" @default.
• W2008259394 hasPublicationYear "2012" @default.
• W2008259394 type Work @default.
• W2008259394 sameAs 2008259394 @default.
• W2008259394 citedByCount "56" @default.
• W2008259394 countsByYear W20082593942012 @default.
• W2008259394 countsByYear W20082593942013 @default.
• W2008259394 countsByYear W20082593942014 @default.
• W2008259394 countsByYear W20082593942015 @default.
• W2008259394 countsByYear W20082593942016 @default.
• W2008259394 countsByYear W20082593942017 @default.
• W2008259394 countsByYear W20082593942018 @default.
• W2008259394 countsByYear W20082593942019 @default.
• W2008259394 countsByYear W20082593942020 @default.
• W2008259394 countsByYear W20082593942021 @default.
• W2008259394 countsByYear W20082593942022 @default.
• W2008259394 countsByYear W20082593942023 @default.
• W2008259394 crossrefType "journal-article" @default.
• W2008259394 hasAuthorship W2008259394A5001656619 @default.
• W2008259394 hasAuthorship W2008259394A5046299969 @default.
• W2008259394 hasAuthorship W2008259394A5072073786 @default.
• W2008259394 hasAuthorship W2008259394A5074628206 @default.
• W2008259394 hasAuthorship W2008259394A5076947309 @default.
• W2008259394 hasConcept C104317684 @default.
• W2008259394 hasConcept C121446783 @default.
• W2008259394 hasConcept C126322002 @default.
• W2008259394 hasConcept C134018914 @default.
• W2008259394 hasConcept C184738001 @default.
• W2008259394 hasConcept C2779064383 @default.
• W2008259394 hasConcept C2780360009 @default.
• W2008259394 hasConcept C38606739 @default.
• W2008259394 hasConcept C502942594 @default.
• W2008259394 hasConcept C54355233 @default.
• W2008259394 hasConcept C555283112 @default.
• W2008259394 hasConcept C71924100 @default.
• W2008259394 hasConcept C86803240 @default.
• W2008259394 hasConceptScore W2008259394C104317684 @default.
• W2008259394 hasConceptScore W2008259394C121446783 @default.
• W2008259394 hasConceptScore W2008259394C126322002 @default.

• next