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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2008261722> ?p ?o ?g. }

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• W2008261722 abstract "Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8)." @default.
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• W2008261722 date "2012-10-03" @default.
• W2008261722 modified "2023-10-16" @default.
• W2008261722 title "A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol" @default.
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• W2008261722 doi "https://doi.org/10.1017/thg.2012.63" @default.
• W2008261722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4333218" @default.
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