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- W2008266454 abstract "The effect of 1-β-d-arabinofuranosylthymine (AraT) on Epstein-Barr virus (EBV) replication was studied using the producer lymphoblastoid cell line P3HR-1. Virus-specific early and late capsid antigens were induced with a tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) alone, or in combination with sodium butyrate. The expression of VCA was completely inhibited by the analog after chemical induction of these cells, whereas no effect on early antigen production or on the increase of an EBV-specific DNA polymerase activity was observed. The activation of P3HR-1 TK− cells by TPA-sodium butyrate induced high stimulation of [3H]thymidine incorporation into the viral DNA, which was entirely inhibited by the analog, as demonstrated by CsCl gradient analysis. The work reported here strongly suggests that AraT is an efficient inhibitor of EBV replication, acting during the period of initiation of viral DNA replication." @default.
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- W2008266454 modified "2023-10-17" @default.
- W2008266454 title "Effects of arabinofuranosylthymine on Epstein-Barr virus replication" @default.
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- W2008266454 doi "https://doi.org/10.1016/0042-6822(80)90379-7" @default.
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