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• W2008267423 endingPage "30" @default.
• W2008267423 startingPage "15" @default.
• W2008267423 abstract "Schizophrenia is believed to arise from complex gene-environment interactions. Brain-derived neurotrophic factor (BDNF) is involved in neuronal development, differentiation and plasticity. A functional single nucleotide polymorphism that results in a valine (Val) to methionine (Met) substitution at codon 66 (Val66Met) results in the aberrant sorting and release of mature BDNF through the activity-dependent secretion pathway. The Val66Met polymorphism has been linked to impaired neurocognitive function in healthy adults, and identified as a locus of risk for a range of neuropsychiatric disorders including schizophrenia. Here we provide a comprehensive review of the relationship between the BDNF Val66Met polymorphism and schizophrenia, integrating evidence from the fields of genetic epidemiology, clinical psychiatry, behavioral neuroscience and neuroimaging. We argue that while the Val66Met polymorphism may not be a major risk-conferring agent for the development of schizophrenia per se, there is mounting evidence that the polymorphism modulates a range of clinical features of the illness, including age of onset, symptoms, therapeutic responsiveness, neurocognitive function and brain morphology." @default.
• W2008267423 created "2016-06-24" @default.
• W2008267423 creator A5023094324 @default.
• W2008267423 creator A5063883134 @default.
• W2008267423 creator A5085322270 @default.
• W2008267423 date "2015-04-01" @default.
• W2008267423 modified "2023-10-06" @default.
• W2008267423 title "A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review" @default.
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